Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering
文献类型：期刊论文
| 作者 | Zhang, Xinxin1,2 ; Zhang, Chi4; Xu, Wei2; Zhong, Biao4; Lin, Feng4; Zhang, Jian4; Wang, Quanxiang3; Ji, Jiajin3; Wei, Jie3; Zhang, Yang2
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2015 |
| 卷号 | 10页码:6699-6708 |
| 关键词 | bone repair polybutylene succinate calcium-magnesium silicate ordered mesoporous proliferation |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S92598 |
| 文献子类 | Article |
| 英文摘要 | The structural features of bone engineering scaffolds are expected to exhibit osteoinductive behavior and promote cell adhesion, proliferation, and differentiation. In the present study, we employed synthesized ordered mesoporous calcium-magnesium silicate (om-CMS) and polybutylene succinate (PBSu) to develop a novel scaffold with potential applications in osseous tissue engineering. The characteristics, in vitro bioactivity of om-CMS/PBSu scaffold, as well as the cellular responses of MC3T3-E1 cells to the composite were investigated. Our results showed that the om-CMS/PBSu scaffold possesses a large surface area and highly ordered channel pores, resulting in improved degradation and biocompatibility compared to the PBSu scaffold. Moreover, the om-CMS/PBSu scaffold exhibited significantly higher bioactivity and induced apatite formation on its surface after immersion in the simulated body fluid. In addition, the om-CMS/PBSu scaffold provided a high surface area for cell attachment and released Ca, Mg, and Si ions to stimulate osteoblast proliferation. The unique surface characteristics and higher biological efficacy of the om-CMS/PBSu scaffold suggest that it has great potential for being developed into a system that can be employed in osseous tissue engineering. |
| WOS关键词 | IN-VITRO BIOACTIVITY ; POLY(BUTYLENE SUCCINATE) ; BONE REGENERATION ; GLASS ; COMPOSITE ; RELEASE ; NANOPARTICLES ; DEGRADATION ; COMBINATION ; IMPLANTS |
| 资助项目 | National Nature Science Foundation of China[81201177] ; National Nature Science Foundation of China[81571796] ; Youth Innovation Promotion Association, CAS[00000000] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000363651500002 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276696]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Shanghai 200336, Peoples R China; 3.E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai 200336, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xinxin,Zhang, Chi,Xu, Wei,et al. Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:6699-6708. |
| APA | Zhang, Xinxin.,Zhang, Chi.,Xu, Wei.,Zhong, Biao.,Lin, Feng.,...&Zhang, Yang.(2015).Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,6699-6708. |
| MLA | Zhang, Xinxin,et al."Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):6699-6708. |
入库方式： OAI收割
来源：上海药物研究所
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