Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism
文献类型：期刊论文
| 作者 | Zhu, Quanlei1,2; Li, Xiuying1,2; Xia, Dengning1; Yu, Hongzhen1,2; Chen, Dan1,2; Fan, Weiwei1,2; Gan, Yong1
|
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:3页码:200-210 |
| 关键词 | Absorption lipid formulations metabolism poorly soluble drug systemic exposure |
| ISSN号 | 1389-2002 |
| DOI | 10.2174/138920021603150812121453 |
| 文献子类 | Article |
| 英文摘要 | The application of lipid-based drug delivery systems on the industrial scale has successfully demonstrated their therapeutic and manufacturing advantages. Recently, various lipid-based formulations were successfully prepared for oral delivery of compounds that are difficult to administer. Nevertheless, an improved understanding of how these formulations affect drug absorption and metabolism is required to support the rapid and successful completion of drug development programs. In this review, we report the detailed mechanisms whereby lipids and lipid-based excipients affect drug absorption and metabolism, and summarize the capacity of lipids and lipid-based formulations to improve drug absorption by improving drug solubility, mucosa penetration, lymphatic transport, and hepatic metabolism. Finally, we discuss the progress made toward the use of novel lipid formulations to enhance oral absorption by surmounting specific absorption barriers. |
| WOS关键词 | IN-VITRO DIGESTION ; INTESTINAL LYMPHATIC TRANSPORT ; POORLY SOLUBLE DRUGS ; P-GLYCOPROTEIN ; LIPOPHILIC DRUGS ; POLYMERIC NANOPARTICLES ; MUCOADHESIVE PROPERTIES ; COATED LIPOSOMES ; CELLULAR UPTAKE ; BIOAVAILABILITY |
| 资助项目 | National Natural Science Foundations of China[81373356] ; "Science and technology innovation action plan for basic research" of Shanghai[14JC1493200] ; National Natural Science Foundation of China[81202468] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000359604700003 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276716]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Quanlei,Li, Xiuying,Xia, Dengning,et al. Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism[J]. CURRENT DRUG METABOLISM,2015,16(3):200-210. |
| APA | Zhu, Quanlei.,Li, Xiuying.,Xia, Dengning.,Yu, Hongzhen.,Chen, Dan.,...&Gan, Yong.(2015).Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism.CURRENT DRUG METABOLISM,16(3),200-210. |
| MLA | Zhu, Quanlei,et al."Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism".CURRENT DRUG METABOLISM 16.3(2015):200-210. |
入库方式： OAI收割
来源：上海药物研究所
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