Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells
文献类型：期刊论文
| 作者 | Liang, Jianming1,2; Zeng, Feng1,2; Zhang, Meng1; Pan, Zhenzhen1,3; Chen, Yingzhi1; Zeng, Yuaner3; Xu, Yong4; Xu, Qin2; Huang, Yongzhuo1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:54页码:43733-43740 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra03083h |
| 文献子类 | Article |
| 英文摘要 | The potent antitumor activities of silver nanoparticles (AgNP) have attracted great attention. However, the application of AgNP is restricted by its non-specific delivery and poor cellular uptake. We developed a novel hyaluronic acid (HA)-based strategy for the green synthesis of AgNP, in which HA was used as the reducing agent and stabilizer. More importantly, HA is a ligand of CD44, and the HA-modified AgNP can target CD44 receptors that are overexpressed in many types of cancer cells. The CD44-dependent endocytosis can significantly increase the intracellular delivery of HA-AgNP, compared to the non-modified one. The antitumor efficacy was significantly improved by HA modification. Furthermore, we found that multiple mechanisms were involved for the enhanced anticancer activities of HA-AgNP, including the decline of mitochondrial membrane potential, cell-cycle arrest, apoptosis, and autophagy. The HA-based strategy for green synthesis and CD44-targeting delivery provided a promising solution for AgNP-mediated cancer treatment. |
| WOS关键词 | COLORECTAL-CANCER ; IN-VIVO ; APOPTOSIS ; EXPRESSION ; AUTOPHAGY ; MONODANSYLCADAVERINE ; PHOSPHATIDYLSERINE ; INHIBITION ; RESISTANCE ; RELEASE |
| 资助项目 | 973 Program, China[2014CB931900] ; 973 Program, China[2013CB932503] ; NSFC, China[81172996] ; NSFC, China[81373357] ; NSFC, China[81422048] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000354964600080 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276729]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 501450, Guangdong, Peoples R China; 3.Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 501450, Guangdong, Peoples R China; 4.Hubei Biol Med Ind Technol Inst Co Ltd, Wuhan 430075, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jianming,Zeng, Feng,Zhang, Meng,et al. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells[J]. RSC ADVANCES,2015,5(54):43733-43740. |
| APA | Liang, Jianming.,Zeng, Feng.,Zhang, Meng.,Pan, Zhenzhen.,Chen, Yingzhi.,...&Huang, Yongzhuo.(2015).Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells.RSC ADVANCES,5(54),43733-43740. |
| MLA | Liang, Jianming,et al."Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells".RSC ADVANCES 5.54(2015):43733-43740. |
入库方式： OAI收割
来源：上海药物研究所
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