A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging
文献类型：期刊论文
| 作者 | Wang, Yaping1,2; Lin, Tingting1,2; Zhang, Wenyuan2; Jiang, Yifan2; Jin, Hongyue2; He, Huining1; Yang, Victor C.1,3; Chen, Yi2 ; Huang, Yongzhuo2
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:8页码:787-795 |
| 关键词 | matrix metalloprotease protease-activatable probe tumor imaging brain tumor fluorescence resonance energy transfer |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.11139 |
| 文献子类 | Article |
| 英文摘要 | Tumor-associated proteases (TAPs) have been intensively studied because of their critical roles in cancer development. As a case in point, expression of matrix metalloproteases (MMP) is significantly up-regulated in tumorigenesis, invasion, and metastasis among a majority of cancers. Here we present a prodrug-type, MMP-2-responsive nanoprobe system with high efficiency and low toxicity for detecting MMP-2-overexpressed tumors. The nanoprobe system is featured by its self-assembled fabrication and FRET effect. This prodrug-type nanoprobe is selectively activated by MMP-2, and thus useful for detection of the MMP-2-overexpressed cells and tumors. The nanoprobe system works successfully in various animal tumor models, including human fibrosarcoma and subcutaneous glioma xenograft. Furthermore, in order to overcome the blood brain barrier (BBB) and achieve brain tumor targeting, a transferrin-receptor targeting peptide (T7 peptide) is strategically incorporated into the nanoprobe. The T7-functionalized nanoprobe is capable of detecting the orthotopic brain tumor, with clear, real-time in vivo imaging. This method is promising for in vivo detection of brain tumor, and real-time monitor of a TAP (i.e., MMP-2). |
| WOS关键词 | MATRIX METALLOPROTEINASE-2 ; NANOPARTICLES ; CANCER ; EXPRESSION ; GLIOMA |
| 资助项目 | National Basic Research Program of China (973 Program)[2013CB932503] ; National Basic Research Program of China (973 Program)[2014CB931900] ; NSFC of China[91029743] ; NSFC of China[81172996] ; NSFC of China[81373357] ; NSFC of China[81361140344] ; NSFC of China[81422048] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000354959900001 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276732]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Michigan, Coll Pharm, Ann Arbor, MI 48108 USA |
| 推荐引用方式 GB/T 7714 | Wang, Yaping,Lin, Tingting,Zhang, Wenyuan,et al. A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging[J]. THERANOSTICS,2015,5(8):787-795. |
| APA | Wang, Yaping.,Lin, Tingting.,Zhang, Wenyuan.,Jiang, Yifan.,Jin, Hongyue.,...&Huang, Yongzhuo.(2015).A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging.THERANOSTICS,5(8),787-795. |
| MLA | Wang, Yaping,et al."A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging".THERANOSTICS 5.8(2015):787-795. |
入库方式： OAI收割
来源：上海药物研究所
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