Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors
文献类型：期刊论文
| 作者 | Wang, Huiyuan2 ; Jiang, Yifan2; Peng, Huige2; Chen, Yingzhi2; Zhu, Peizhi1; Huang, Yongzhuo2
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| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2015-01 |
| 卷号 | 81页码:142-160 |
| 关键词 | MicroRNA Drug delivery Non-viral vector Synthetic vector Cancer therapy |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2014.10.031 |
| 文献子类 | Review |
| 英文摘要 | MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Because of significant changes in their expression in cancer, miRNAs are believed to be key factors in cancer genetics and to have potential as anticancer drugs. However, the delivery of miRNAs is limited by many barriers, such as low cellular uptake, immunogenicity, renal clearance, degradation by nucleases, elimination by phagocytic immune cells, poor endosomal release, and untoward side effects. Nonviral delivery systems have been developed to overcome these obstacles. In this review, we provide insights into the development of non-viral synthetic miRNA vectors and the promise of miRNA-based anticancer therapies, including therapeutic applications of miRNAs, challenges of vector design to overcome the delivery obstacles, and the development of miRNA delivery systems for cancer therapy. Additionally, we highlight some representative examples that give a glimpse into the current trends into the design and application of efficient synthetic systems for miRNA delivery. Overall, a better understanding of the rational design of miRNA delivery systems will promote their translation into effective clinical treatments. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | SMALL INTERFERING RNA ; MOLECULAR-WEIGHT POLYETHYLENIMINE ; NANOPARTICLE-MEDIATED DELIVERY ; SHORT BRANCH PEI ; GENE DELIVERY ; IN-VIVO ; LUNG-CANCER ; REPLACEMENT THERAPY ; TARGETED DELIVERY ; SYSTEMIC DELIVERY |
| 资助项目 | National Basic Research Program of China (973 Program)[2014CB931902] ; National Basic Research Program of China (973 Program)[2013CB932503] ; NSFC, China[81172996] ; NSFC, China[81373357] ; NSFC, China[81422048] ; NSFC, China[81402883] ; Chinese Postdoctoral Science Foundation[2012M510097] ; Chinese Postdoctoral Science Foundation[2013T60478] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000348621600012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276759]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225009, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Huiyuan,Jiang, Yifan,Peng, Huige,et al. Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors[J]. ADVANCED DRUG DELIVERY REVIEWS,2015,81:142-160. |
| APA | Wang, Huiyuan,Jiang, Yifan,Peng, Huige,Chen, Yingzhi,Zhu, Peizhi,&Huang, Yongzhuo.(2015).Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors.ADVANCED DRUG DELIVERY REVIEWS,81,142-160. |
| MLA | Wang, Huiyuan,et al."Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors".ADVANCED DRUG DELIVERY REVIEWS 81(2015):142-160. |
入库方式： OAI收割
来源：上海药物研究所
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