In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography
文献类型：期刊论文
| 作者 | Wang, Jing3; Xie, Yadian2,3; Wang, Liming3; Tang, Jinglong3; Li, Jiayang3; Kocaefe, Duygu2; Kocaefe, Yasar2; Zhang, Zhiwen1 ; Li, Yaping1; Chen, Chunying3
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:10页码:7529-7538 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c4ra13228a |
| 文献子类 | Article |
| 英文摘要 | Metallic nanomaterials, especially gold nanoparticles, which have low toxicity and high photothermal conversion efficiency, exhibit promising theranostic applications in biomedical fields. However, detailed preclinical studies of these nanomaterials, such as pharmacokinetics, metabolism, long-term stability and toxicity potential should still be performed. Photoacoustic imaging as a novel non-invasive imaging technique provides convenience for studying real-time semiquantitative pharmacokinetic and biodistribution profiles of drugs or probes to determine whether they can reach the target areas and their metabolic pathways. In this article, we prepared chitosan-capped star shaped gold nanoparticles (AuNSs) and used multispectral optoacoustic tomography (MSOT) to visualize AuNSs in the blood vessels, liver, spleen and kidneys in real time. We also compared these results with chitosan-capped rod shaped gold nanoparticles (AuNRs). The results show that both AuNSs and AuNRs experience rapid blood clearance and have fast and long-term accumulation in the liver and spleen (reaching the peak value within 10 min). The pharmacokinetic data of the two gold nanoparticles fitted to the two-compartment model. The important pharmacokinetic parameters were calculated. The results from MSOT were qualitatively validated by inductively coupled plasma mass spectrometery (ICP-MS). Our results demonstrate that MSOT can serve as an effective tool to monitor gold nanoparticles' pharmacokinetics and biodistribution in specific organs. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; PHOTOACOUSTIC TOMOGRAPHY ; CANCER-THERAPY ; NANORODS ; DELIVERY ; LASER ; SIZE ; HYPERTHERMIA ; CHEMOTHERAPY ; NANOSTARS |
| 资助项目 | Ministry of Science and Technology of China (National Basic Research Programs)[2011CB933401] ; Ministry of Science and Technology of China (National Basic Research Programs)[2012CB934003] ; International Science & Technology Cooperation Program of China[00000000] ; Ministry of Science Technology of China[2013DFG32340] ; Ministry of Science Technology of China[2014DFG52500] ; National Major Scientific Instruments Development Project[2011YQ03013406] ; National Science Foundation of China[21320102003] ; National Science Foundation of China[11205166] ; National Science Fund for Distinguished Young Scholars[11425520] ; State Scholarship Fund of China Scholarship Council[201307970002] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000347609400064 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276772]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Quebec Chicoutimi UQAC, Dept Appl Sci, Quebec City, PQ, Canada; 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Xie, Yadian,Wang, Liming,et al. In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography[J]. RSC ADVANCES,2015,5(10):7529-7538. |
| APA | Wang, Jing.,Xie, Yadian.,Wang, Liming.,Tang, Jinglong.,Li, Jiayang.,...&Chen, Chunying.(2015).In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography.RSC ADVANCES,5(10),7529-7538. |
| MLA | Wang, Jing,et al."In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography".RSC ADVANCES 5.10(2015):7529-7538. |
入库方式： OAI收割
来源：上海药物研究所
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