Nanoassembly of Probucol Enables Novel Therapeutic Efficacy in the Suppression of Lung Metastasis of Breast Cancer
文献类型：期刊论文
| 作者 | Zhang, Zhiwen2 ; Cao, Haiqiang2; Jiang, Shijun1; Liu, Zeying1; He, Xinyu2; Yu, Haijun2; Li, Yaping2
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| 刊名 | SMALL
 |
| 出版日期 | 2014-11-26 |
| 卷号 | 10期号:22页码:4735-4745 |
| 关键词 | nanoassembly probucol biomedical applications drug delivery |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201400799 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is one of the major obstacles hindering the success of cancer therapy. The directed nanoassembly of probucol results in the DNP system, which greatly improves the oral delivery of probucol and subsequently leads to a novel therapeutic efficacy of probucol in the suppression of lung metastasis of breast cancer. DNP is formed by employing the intermolecular hydrophobic interactions between probucol and polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether (also known as Triton X-100). After oral administration, the probucol concentration in the intestines is surprisingly about 200 times higher if it is applied as DNP rather than free probucol; it can be absorbed into intestinal enterocytes via clathrin-mediated endocytosis and transported into the systemic circulation through the lymphatic pathway. Moreover, the oral bioavailability of probucol is significantly higher13.55 times higherwhen applied as DNP in place of free probucol. The drug concentration in major organs is also significantly increased. The in vitro measurements show that the migration and invasion abilities of 4T1 cells are obviously inhibited by DNP. In particular, in an orthotopic metastatic breast cancer model, the notable suppression of lung metastasis from DNP is observed, but no effect is seen from the free-probucol suspension. As a result, the directed drug nanoassembly may open a new route for enhancing oral drug delivery and enable new therapeutic abilities for probucol against cancer metastasis. |
| WOS关键词 | INTESTINAL LYMPHATIC TRANSPORT ; ORAL DELIVERY ; MATRIX METALLOPROTEINASES ; COMPLEX NANOPARTICLES ; DRUG-DELIVERY ; NANOMEDICINE ; INHIBITION ; TUMOR ; RATS ; BIOAVAILABILITY |
| 资助项目 | National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2010CB934000] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; Shanghai program[12nm0501300] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000345366800026 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276827]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Cao, Haiqiang,Jiang, Shijun,et al. Nanoassembly of Probucol Enables Novel Therapeutic Efficacy in the Suppression of Lung Metastasis of Breast Cancer[J]. SMALL,2014,10(22):4735-4745. |
| APA | Zhang, Zhiwen.,Cao, Haiqiang.,Jiang, Shijun.,Liu, Zeying.,He, Xinyu.,...&Li, Yaping.(2014).Nanoassembly of Probucol Enables Novel Therapeutic Efficacy in the Suppression of Lung Metastasis of Breast Cancer.SMALL,10(22),4735-4745. |
| MLA | Zhang, Zhiwen,et al."Nanoassembly of Probucol Enables Novel Therapeutic Efficacy in the Suppression of Lung Metastasis of Breast Cancer".SMALL 10.22(2014):4735-4745. |
入库方式： OAI收割
来源：上海药物研究所
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