Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography
文献类型：期刊论文
| 作者 | Wang, Caifen3,4; Ge, Jingwen3,4; Zhang, Jiwen1,3 ; Guo, Tao3; Chi, Liandi3; He, Zhonggui4; Xu, Xu1; York, Peter2; Sun, Lixin4; Li, Haiyan3
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| 刊名 | JOURNAL OF CHROMATOGRAPHY A
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| 出版日期 | 2014-09-12 |
| 卷号 | 1359页码:287-295 |
| 关键词 | Kinetic studies Modified peak profiling method Cyclodextrin supramolecular systems Mobile phase composition Multianalyte approach |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2014.07.012 |
| 文献子类 | Article |
| 英文摘要 | The kinetics of the dissociation is fundamental to the formation and the in vivo performance of cyclodextrin supramolecules. The individual determination of the apparent dissociation rate constant (k(d,app)) using high performance affinity chromatography (HPAC) is a tedious process requiring numerous separate studies and massive data fitting. In this study, the multianalyte approach was employed to simultaneously measure the k(d,app) values of three drugs through one injection based on the investigation of the dependence of drug-cyclodextrin interaction kinetics on the mobile phase composition. As a result, the k(d,app) values increased when decreasing the ion strength, increasing the ionization of drugs and adding extra organic solvents. The values of k(d,app) for acetaminophen, phenacetin and S-flurbiprofen estimated by the multianalyte approach were 8.54 +/- 1.81, 5.36 +/- 0.94 and 0.17 +/- 0.02 s(-1), respectively, which were in good agreement with those determined separately (8.31 +/- 0.58, 5.01 +/- 0.42 and 0.15 +/- 0.01 s(-1)). For both of the single and multiple flow rate peak profiling methods, the results of the multianalyte approach were statistically equivalent with that of the single compound analysis for all of the three drugs (p>0.05). The multianalyte approach can be employed for the efficient evaluation of the drug-cyclodextrin kinetics with less variance caused by cyclodextrin column bleeding. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; PROTEIN DISSOCIATION RATES ; NANO-LIQUID CHROMATOGRAPHY ; PEAK DECAY ANALYSIS ; BETA-CYCLODEXTRIN ; ENANTIOMERIC SEPARATION ; ALPHA-CYCLODEXTRIN ; BINDING-KINETICS ; CHIRAL SOLUTES ; L-TRYPTOPHAN |
| 资助项目 | National Natural Science Foundation of China[81373358] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000340984400035 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276906]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Haiyan |
| 作者单位 | 1.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 2.Univ Bradford, Bradford BD7 1DP, W Yorkshire, England 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Caifen,Ge, Jingwen,Zhang, Jiwen,et al. Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1359:287-295. |
| APA | Wang, Caifen.,Ge, Jingwen.,Zhang, Jiwen.,Guo, Tao.,Chi, Liandi.,...&Li, Haiyan.(2014).Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography.JOURNAL OF CHROMATOGRAPHY A,1359,287-295. |
| MLA | Wang, Caifen,et al."Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography".JOURNAL OF CHROMATOGRAPHY A 1359(2014):287-295. |
入库方式： OAI收割
来源：上海药物研究所
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