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Directed Self-assembled Nanoparticles of Probucol Improve Oral Delivery: Fabrication, Performance and Correlation

文献类型：期刊论文

作者Zhang, Zhiwen1; Jiang, Shijun2; Liu, Zeying2; Niu, Baohua1; Gu, Wangwen1; Li, Yaping1; Cui, Jingbin2
刊名PHARMACEUTICAL RESEARCH
出版日期2014-09
卷号31期号:9页码:2266-2275
关键词correlation directed self-assembly nanoparticles oral delivery probucol
ISSN号0724-8741
DOI10.1007/s11095-014-1321-7
文献子类Article
英文摘要We are reporting on the development of a unique drug delivery platform by directed self-assembly technique to improve the oral delivery of hydrophobic drugs. Herein, a series of probucol directed self-assembled nanoparticles (PDN) were developed with two components of probucol and surfactant such as Tween 20, Tween 80, D-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) and HS-15, which was respectively named as T-20-PDN, T-80-PDN, TP-PDN and HS-PDN. The formation of various PDNs was determined by in vitro characterization and the physicochemical properties of these PDNs were determined. Moreover, the performance of PDN in enhancing the oral delivery and possible correlation between the in vitro properties and in vivo performances were investigated. PDN was homogenous nanometer-sized particles with negative surface charge. The cellular uptake of probucol in Caco-2 cell monolayer was respectively increased 1.15, 1.82, 1.59 and 5.31-fold by these PDN. In particular, the oral bioavailability of these PDN was significantly improved 3.0, 4.1, 5.4 and 10.4 folds compared with the free drug suspension. The enhanced cellular uptake and oral bioavailability were correlated with the characters of involved surfactants and the particle size of PDN. Thereby, the directed self-assembled nanoparticles could provide a new strategy for enhancing the oral delivery of hydrophobic drugs.
WOS关键词LIPID-BASED FORMULATIONS ; IN-VITRO CHARACTERISTICS ; WATER-SOLUBLE DRUGS ; POLYMERIC NANOPARTICLES ; LIPOPHILIC DRUGS ; ABSORPTION ; SYSTEM ; BIOAVAILABILITY ; MECHANISM ; RATS
资助项目The National Basic Research Program of China[2013CB932503] ; The National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; SA-SIBS Scholarship Program[00000000]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000343133900003
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://119.78.100.183/handle/2S10ELR8/276915]  
专题药物制剂研究中心
通讯作者Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zhiwen,Jiang, Shijun,Liu, Zeying,et al. Directed Self-assembled Nanoparticles of Probucol Improve Oral Delivery: Fabrication, Performance and Correlation[J]. PHARMACEUTICAL RESEARCH,2014,31(9):2266-2275.
APA Zhang, Zhiwen.,Jiang, Shijun.,Liu, Zeying.,Niu, Baohua.,Gu, Wangwen.,...&Cui, Jingbin.(2014).Directed Self-assembled Nanoparticles of Probucol Improve Oral Delivery: Fabrication, Performance and Correlation.PHARMACEUTICAL RESEARCH,31(9),2266-2275.
MLA Zhang, Zhiwen,et al."Directed Self-assembled Nanoparticles of Probucol Improve Oral Delivery: Fabrication, Performance and Correlation".PHARMACEUTICAL RESEARCH 31.9(2014):2266-2275.

入库方式： OAI收割

来源：上海药物研究所

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