Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods
文献类型：期刊论文
| 作者 | Wang, Dangge3; Xu, Zhiai2; Yu, Haijun3 ; Chen, Xianzhi3; Feng, Bing3; Cui, Zhirui3; Lin, Bin2; Yin, Qi3; Zhang, Zhiwen3; Chen, Chunying4
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2014-09 |
| 卷号 | 35期号:29页码:8374-8384 |
| 关键词 | Metastatic breast cancer Gold nanorods Doxorubicin Photothermal ablation Chemotherapy |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2014.05.094 |
| 文献子类 | Article |
| 英文摘要 | Despite the exciting advances in cancer therapy over past decades, tumor metastasis remains the dominate reason for cancer-related mortality. In present work, DNA-wrapped gold nanorods with doxorubicin (DOX)-loading (GNR@DOX) were developed for treatment of metastatic breast cancer via a combination of chemotherapy and photothermal ablation. The GNR@DOX nanoparticles induced significant temperature elevation and DOX release upon irradiation with near infrared (NIR) light as shown in the test tube studies. It was found that GNR@DOX nanoparticles in combination with laser irradiation caused higher cytotoxicity than free DOX in 4T1 breast cancer cells. Animal experiment with an orthotropic 4T1 mammary tumor model demonstrated that GNR@DOX nanoplatform significantly reduced the growth of primary tumors and suppressed their lung metastasis. The Hematoxylin and Eosin (H&E) and immunohistochemistry (IHC) staining assays confirmed that the tumor growth inhibition and metastasis prevention of GNR@DOX nanoparticles were attributed to their abilities to induce cellular apoptosis/necrosis and ablate intratumoral blood vessels. All these results suggested a considerable potential of GNR@DOX nanoplatform for treatment of metastatic breast cancer. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | LYMPH-NODE METASTASES ; IN-VITRO ; TUMOR VASCULATURE ; SENTINEL NODE ; THERAPY ; NANOPARTICLES ; ANGIOGENESIS ; DELIVERY ; PLATFORM ; BINDING |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[21305047] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000340853400010 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276925]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China 2.E China Normal Univ, Dept Chem, Shanghai 200241, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Dangge,Xu, Zhiai,Yu, Haijun,et al. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods[J]. BIOMATERIALS,2014,35(29):8374-8384. |
| APA | Wang, Dangge.,Xu, Zhiai.,Yu, Haijun.,Chen, Xianzhi.,Feng, Bing.,...&Li, Yaping.(2014).Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods.BIOMATERIALS,35(29),8374-8384. |
| MLA | Wang, Dangge,et al."Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods".BIOMATERIALS 35.29(2014):8374-8384. |
入库方式： OAI收割
来源：上海药物研究所
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