Orally active-targeted drug delivery systems for proteins and peptides
文献类型：期刊论文
| 作者 | Li, Xiuying3; Yu, Miaorong3; Fan, Weiwei3; Gan, Yong3 ; Hovgaard, Lars2; Yang, Mingshi1
|
| 刊名 | EXPERT OPINION ON DRUG DELIVERY
 |
| 出版日期 | 2014-09 |
| 卷号 | 11期号:9页码:1435-1447 |
| 关键词 | active-targeted drug delivery systems IgG-Fc receptor intercellular adhesion molecule-1 oral protein and peptide delivery proton-coupled folate transporter recombinant fusion protein transferrin receptor |
| ISSN号 | 1742-5247 |
| DOI | 10.1517/17425247.2014.924500 |
| 文献子类 | Review |
| 英文摘要 | Introduction: In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption. Areas covered: This review focuses on recent advances with orally ATDDS, including ligand-protein conjugates, recombinant ligand-protein fusion proteins and ligand-modified carriers. In addition to traditional intestinal active transport systems of substrates and their corresponding receptors, transporters and carriers, new targets such as intercellular adhesion molecule-1 and beta-integrin are also discussed. Expert opinion: ATDDS can improve oral absorption of proteins and peptides. However, currently, no clinical studies on ATDDS for proteins and peptides are underway, perhaps due to the complexity and limited knowledge of transport mechanisms. Therefore, more research is warranted to optimize ATDDS efficiency. |
| WOS关键词 | GLUCAGON-LIKE PEPTIDE-1 ; INSULIN DELIVERY ; EPITHELIAL-CELLS ; IN-VITRO ; FUNCTIONALIZED NANOPARTICLES ; PLGA NANOPARTICLES ; PARTICLE-TRANSPORT ; PERORAL DELIVERY ; DIABETIC-RATS ; LIPOSOMES |
| 资助项目 | Novo Nordisk-Chinese Academy of Science (CAS) Research Foundation[NNCAS-2012-04] ; National Science and Technology Major Project, 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000340770300009 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276928]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, DK-2100 Copenhagen, Denmark 2.Novo Nordisk AS, Oral Formulat Dev, DK-2760 Malov, Denmark; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Xiuying,Yu, Miaorong,Fan, Weiwei,et al. Orally active-targeted drug delivery systems for proteins and peptides[J]. EXPERT OPINION ON DRUG DELIVERY,2014,11(9):1435-1447. |
| APA | Li, Xiuying,Yu, Miaorong,Fan, Weiwei,Gan, Yong,Hovgaard, Lars,&Yang, Mingshi.(2014).Orally active-targeted drug delivery systems for proteins and peptides.EXPERT OPINION ON DRUG DELIVERY,11(9),1435-1447. |
| MLA | Li, Xiuying,et al."Orally active-targeted drug delivery systems for proteins and peptides".EXPERT OPINION ON DRUG DELIVERY 11.9(2014):1435-1447. |
入库方式： OAI收割
来源：上海药物研究所
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