A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer
文献类型：期刊论文
| 作者 | Bu, Huihui; He, Xinyu; Zhang, Zhiwen ; Yin, Qi; Yu, Haijun; Li, Yaping
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2014-08-25 |
| 卷号 | 471期号:1-2页码:206-213 |
| 关键词 | Paclitaxel Self-assembly TPGS Nanoemulsion Multidrug resistance Breast cancer |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2014.05.039 |
| 文献子类 | Article |
| 英文摘要 | Paclitaxel resistance is usually developed in clinical chemotherapy, which remains a major obstacle for successful cancer treatment. Herein, we attempted to develop a TPGS incorporating nanoemulsion of paclitaxel (NE-PTX) to circumvent the drug resistance in breast cancer. NE-PTX was prepared by a self-assembly technique and the physicochemical properties were characterized. The efficacy of NE-PTX on overcoming paclitaxel resistance was measured by in vitro and in vivo evaluation. The measured results indicated that NE-PTX was nanometer-sized droplets with the mean diameter of 24.93 +/- 3.45 nm. The IC50 value of paclitaxel in resistant MCF-7/ADR cells was greatly reduced from 101.45 mg/mL to 5.39 mg/mL, which indicated that the paclitaxel resistance was effectively reduced by NE-PTX. The reversal of paclitaxel resistance could mainly ascribe to the significant inhibition of P-gp activity and enhancement of anti-cancer activity. Moreover, the tumor volume in resistant tumor xenograft model treated with NE-PTX was only 10.06% of that of paclitaxel solution group, and the tumor inhibitory rate of NE-PTX reached 93.84%, which effectively verified the efficacy of NE-PTX on treating paclitaxel resistance. Thereby, NE-PTX could provide an effective strategy for circumventing paclitaxel resistance in breast cancer. (C) 2014 Elsevier B. V. All rights reserved. |
| WOS关键词 | OVERCOME MULTIDRUG-RESISTANCE ; SERUM-ALBUMIN NANOPARTICLES ; IN-VIVO EVALUATION ; ANTITUMOR-ACTIVITY ; TARGETED DELIVERY ; P-GLYCOPROTEIN ; OVARIAN-CANCER ; VITRO ; MITOCHONDRIA ; LIPOSOMES |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81102388] ; National Natural Science Foundation of China[81230029] ; Shanghai Nanomedicine Program[11nm0505900] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000338423600026 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276936]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Zhiwen |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bu, Huihui,He, Xinyu,Zhang, Zhiwen,et al. A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2014,471(1-2):206-213. |
| APA | Bu, Huihui,He, Xinyu,Zhang, Zhiwen,Yin, Qi,Yu, Haijun,&Li, Yaping.(2014).A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer.INTERNATIONAL JOURNAL OF PHARMACEUTICS,471(1-2),206-213. |
| MLA | Bu, Huihui,et al."A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer".INTERNATIONAL JOURNAL OF PHARMACEUTICS 471.1-2(2014):206-213. |
入库方式： OAI收割
来源：上海药物研究所
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