Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis
文献类型：期刊论文
| 作者 | Xu, Pengfei2; Yu, Haijun2 ; Zhang, Zhiwen2; Meng, Qingshuo2; Sun, Huiping1,2; Chen, Xianzhi1,2; Yin, Qi2; Li, Yaping2
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014-08 |
| 卷号 | 35期号:26页码:7574-7587 |
| 关键词 | Micelles Atorvastatin Metastasis Polyethylene glycol-s-s-vitamin E succinate Reduction-responsive |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2014.05.030 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug delivery system loading atorvastatin calcium (Ator) was developed for the efficient suppression of the metastasis of breast cancer. The nano-drug delivery system was constructed by a amphiphilic copolymer of methoxy polyethylene glycol-s-s-vitamin E succinate (mPEG-s-s-VES, PSV), which was consisted of a hydrophilic mPEG(1k), segment and a hydrophobic 'VES head, which were conjugated with a linker bearing amide and disulfide groups simultaneously. Self-assembly of PSV and Ator formed Ator-loaded PSV micelles (ASM) with good colloidal stability, high drug loading content (up to 50%) and great encapsulation efficiency (99.09 +/- 0.28%). In cellular level, it was found that the ASM could efficiently release the Ator payload into cytosol due to detachment of PEG shell at high intracellular glutathione condition. ASM could significantly inhibit the migration and invasion of 4T1 breast cancer cells with inhibitory rates of 79.2% and 88.5%, respectively. In a 4T1 orthotropic mammary tumor metastatic cancer model, it was demonstrated that ASM could completely blocked the lung and liver metastasis of breast cancer with minimal toxicity owing to enhanced Ator accumulation in tumor and lung as compared with that of free Ator. The downregulations of metastasis-promoting MMP-9, Twist and uPA proteins were demonstrated as the main underlying mechanism. As a result, ASM could be a promising drug delivery system for the efficient therapy of breast cancer metastasis. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | POLYMERIC NANOPARTICLES ; DRUG-DELIVERY ; MATRIX METALLOPROTEINASES ; MULTIDRUG-RESISTANCE ; LIPID NANOPARTICLES ; TUMOR-METASTASIS ; BLOCK-COPOLYMER ; SIRNA DELIVERY ; CELL INVASION ; IN-VITRO |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; Shanghai program[12nm0501300] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000339035000031 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276974]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Pengfei,Yu, Haijun,Zhang, Zhiwen,et al. Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis[J]. BIOMATERIALS,2014,35(26):7574-7587. |
| APA | Xu, Pengfei.,Yu, Haijun.,Zhang, Zhiwen.,Meng, Qingshuo.,Sun, Huiping.,...&Li, Yaping.(2014).Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis.BIOMATERIALS,35(26),7574-7587. |
| MLA | Xu, Pengfei,et al."Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis".BIOMATERIALS 35.26(2014):7574-7587. |
入库方式： OAI收割
来源：上海药物研究所
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