Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH-Responsive Theranostic Platform
文献类型：期刊论文
| 作者 | Wu, Meiying3; Meng, Qingshuo1; Chen, Yu3; Xu, Pengfei1; Zhang, Shengjian2; Li, Yaping1 ; Zhang, Lingxia3; Wang, Min3; Yao, Heliang3; Shi, Jianlin3
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2014-07-16 |
| 卷号 | 24期号:27页码:4273-4283 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201400256 |
| 文献子类 | Article |
| 英文摘要 | A unique mesoporous silica nanoparticles (MSNs)-based theranostic platform with ultrasmall iron oxide nanoparticles (NPs) confined within mesopore network has been developed by a facile but efficient physical-vapor-infiltration (PVI) method. The highly dispersed Fe species within mesopore channels can synchronously function as the non-toxic contrast agents for highly efficient T-1-weighted MR imaging, and as anchoring sites for anti-cancer drug molecule loading and pH-responsive release based on the special metal-ligand coordination bonding between the Fe species and drug molecules. Moreover, the obtained Fe-MSNs exhibit favorable biocompatibility, enhanced chemotherapeutic efficacy and concurrently diminished side effects due to the non-specific attack of chemotherapeutic drugs, as well as the capability in circumventing the multidrug resistance (MDR) of cancer cells and suppressing the metastasis of tumor cells in vitro and in vivo. This pH-resoponsive theranostic agent provides a new promising MSNs-based anti-cancer nanomedicine for future biomedical application. |
| WOS关键词 | IMAGING CONTRAST AGENTS ; ANTICANCER DRUG-DELIVERY ; MESOPOROUS SILICA ; CANCER NANOTHERANOSTICS ; TUMOR-METASTASIS ; GUEST MOLECULES ; BREAST-CANCER ; PARTICLE-SIZE ; THERAPY ; RESISTANCE |
| 资助项目 | National Key Basic Research Program of China (973 Program)[2011CB707905] ; National Key Basic Research Program of China (973 Program)[2010CB934000] ; National Nature Science Foundation of China[51302293] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[51072212] ; National Nature Science Foundation of China[81270047] ; National Nature Science Foundation of China[21177137] ; China National Funds for Distinguished Young Scientists[51225202] ; National Natural Science Foundation of Shanghai[11nm0506500] ; Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201203] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000339713500008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276985]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Wu, Meiying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, Shanghai Med Coll, Canc Hosp Inst & Dept Oncol, Dept Radiol, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Meiying,Meng, Qingshuo,Chen, Yu,et al. Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH-Responsive Theranostic Platform[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(27):4273-4283. |
| APA | Wu, Meiying.,Meng, Qingshuo.,Chen, Yu.,Xu, Pengfei.,Zhang, Shengjian.,...&Shi, Jianlin.(2014).Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH-Responsive Theranostic Platform.ADVANCED FUNCTIONAL MATERIALS,24(27),4273-4283. |
| MLA | Wu, Meiying,et al."Ultrasmall Confined Iron Oxide Nanoparticle MSNs as a pH-Responsive Theranostic Platform".ADVANCED FUNCTIONAL MATERIALS 24.27(2014):4273-4283. |
入库方式： OAI收割
来源：上海药物研究所
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