Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile
文献类型：期刊论文
| 作者 | Yang, Shuo1,6; Yin, Xianzhen1,5; Wang, Caifen1,4; Li, Haiyan1 ; He, You3; Xiao, Tiqiao3; Sun, Lixin4; Li, Jiasheng2; York, Peter1,5; He, Jun6
|
| 刊名 | AAPS JOURNAL
 |
| 出版日期 | 2014-07 |
| 卷号 | 16期号:4页码:860-871 |
| 关键词 | microstructure release kinetics single pellet synchrotron radiation X-ray computed microtomography |
| ISSN号 | 1550-7416 |
| DOI | 10.1208/s12248-014-9611-x |
| 文献子类 | Article |
| 英文摘要 | Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-mu CT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from single pellets. The data from the single pellet dissolution measurements demonstrated that the release profile of capsules containing approximately 1,000 pellets per unit dose was the summation of the release profiles of the individual pellets. The release profiles of single tamsulosin hydrochloride (TSH) pellets formed three groups when a cluster analysis was performed, and the dissolution rate of the individual pellets correlated well with the combined effects of the drug loading, volume and surface area of the pellets (R (2) = 0.9429). In addition, the void microstructures within the pellet were critical during drug release. Therefore, SR-mu CT is a powerful tool for quantitatively elucidating the three-dimensional microstructure of the individual pellets; because the microstructure controls drug release, it is an important parameter in the quality control of multi-pellet formulations. |
| WOS关键词 | MULTIPARTICULATE SYSTEMS ; MECHANISM INTERPRETATION ; SURFACE-AREA ; SOLUBLE DRUG ; KINETICS ; MICROSPHERES ; FUNDAMENTALS ; FORMULATION ; ADSORPTION ; SIMULATION |
| 资助项目 | Natural Science Foundation of China[81273453] ; State Key Laboratory of Long-acting and Targeting Drug Delivery System[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000338337400023 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277007]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Li, Jiasheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 2.Wanhe Pharmaceut Co Ltd, Shenzhen 518000, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 5.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 6.Guizhou Prov Biochem Engn Ctr, Guiyang 550025, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Shuo,Yin, Xianzhen,Wang, Caifen,et al. Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile[J]. AAPS JOURNAL,2014,16(4):860-871. |
| APA | Yang, Shuo.,Yin, Xianzhen.,Wang, Caifen.,Li, Haiyan.,He, You.,...&Zhang, Jiwen.(2014).Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile.AAPS JOURNAL,16(4),860-871. |
| MLA | Yang, Shuo,et al."Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile".AAPS JOURNAL 16.4(2014):860-871. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。