Co-delivery of doxorubicin and RNA using pH-sensitive poly (beta-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer
文献类型：期刊论文
| 作者 | Tang, Shan; Yin, Qi ; Zhang, Zhiwen; Gu, Wangwen; Chen, Lingli; Yu, Haijun; Huang, Yongzhuo; Chen, Xianzhi; Xu, Minghua; Li, Yaping
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014-07 |
| 卷号 | 35期号:23页码:6047-6059 |
| 关键词 | Co-delivery Doxorubicin Multidrug resistance PH-sensitive Poly (beta-amino ester) RNA interference |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2014.04.025 |
| 文献子类 | Article |
| 英文摘要 | An appropriate co-delivery system for chemotherapeutic agents and nucleic acid drugs will provide a more efficacious approach for the treatment of breast cancer by reversing multidrug resistance (MDR). In this work, a new amphiphilic poly (beta-amino ester), poly[(1,4-butanediol)-diacrylate-beta-5-polyethylenimine]-block-poly[(1,4-butanediol)-diacrylate-beta-5-hydroxy amylamine] (PDP-PDHA) was synthesized, and the doxorubicin (DOX) and survivin-targeting shRNA (shSur) co-loading nanoparticle (PDNs) were prepared. The pH-sensitive poly[(1,4-butanediol) diacrylate-beta-5-hydroxy amylamine] (PDHA) endowed PDNs both pH-triggered drug release characteristics and enhanced endo/lysosomal escape ability, thus improving the cytotoxicity of DOX and the transfection efficiency. PDNs also increased the DOX accumulation, down-regulated 57.7% survivin expression, induced 80.8% cell apoptosis and changed the cell cycle in MCF-7/ADR cells. In the MCF-7/ADR tumor-bearing mice models, after administrated intravenously, PDNs raised the accumulation of DOX and shSur in the tumor tissue by 10.4 and 20.2 folds, respectively, resulting in obvious inhibition of the tumor growth with tumor inhibiting rate of 95.9%. The combination of DOX and RNA interference showed synergistic effect on overcoming MDR. Therefore, PDNs could be a promising co-delivery vector for effective therapy of drug resistant breast cancer. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | GENE DELIVERY ; INTRACELLULAR TRAFFICKING ; INTERFERING RNAS ; DRUG-RESISTANCE ; FLIP-FLOP ; THERAPY ; CELLS ; NANOCARRIERS ; TRANSFECTION ; EXPRESSION |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2014CB931902] ; National Natural Science Foundation of China[81230029] ; National Natural Science Foundation of China[81302712] ; Shanghai Program[11nm0505900] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000337212200007 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277016]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Medico, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Shan,Yin, Qi,Zhang, Zhiwen,et al. Co-delivery of doxorubicin and RNA using pH-sensitive poly (beta-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer[J]. BIOMATERIALS,2014,35(23):6047-6059. |
| APA | Tang, Shan.,Yin, Qi.,Zhang, Zhiwen.,Gu, Wangwen.,Chen, Lingli.,...&Li, Yaping.(2014).Co-delivery of doxorubicin and RNA using pH-sensitive poly (beta-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer.BIOMATERIALS,35(23),6047-6059. |
| MLA | Tang, Shan,et al."Co-delivery of doxorubicin and RNA using pH-sensitive poly (beta-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer".BIOMATERIALS 35.23(2014):6047-6059. |
入库方式： OAI收割
来源：上海药物研究所
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