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The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer

文献类型：期刊论文

作者Zhang, Zhiwen2; Niu, Baohua1; Chen, Jian3; He, Xinyu1; Bao, Xiaoyue1; Zhu, Jianhua3; Yu, Haijun2; Li, Yaping2
刊名BIOMATERIALS
出版日期2014-05
卷号35期号:15页码:4565-4572
关键词Nanodiamond Sorafenib Oral delivery Cancer metastasis Gastric cancer
ISSN号0142-9612
DOI10.1016/j.biomaterials.2014.02.024
文献子类Article
英文摘要The metastasis is one of the greatest challenges for successful cancer therapy. Herein, we report a lipid-coated nanodiamond (ND) system loading water-insoluble sorafenib (SND) to improve the bioavailability and efficacy on suppression of cancer metastasis. SND was homogenous nanoassemblies with the mean diameter of 127.6 +/- 12.9 nm. Compared with the drug suspension, the sorafenib concentration in gastrointestinal (GI) tract and major organs was significantly increased by SND. Moreover, the oral bioavailability of sorafenib was greatly improved 7.64-fold by SND. However, the ND in SND could not be absorbed into the mucus of GI tract or distributed into major organs after oral administration. Furthermore, the sorafenib concentration in tumor tissue was markedly improved 14.95 folds by SND, and SND demonstrated an efficient and impressive tumor growth inhibition effect in tumor xenograft models. In particular, the metastasis of gastric cancer to distant organs of liver and kidney was remarkably suppressed by SND, which was verified by the detection of macroscopic metastatic nodules, histological examination and immunofluorescence measurements. Thereby, the lipid-coated ND could be a promising drug delivery platform for improving the oral bioavailability of lipophilic drugs and treatment of cancer metastasis. (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词IN-VIVO ; DRUG-DELIVERY ; FLUORESCENT NANODIAMOND ; TUMOR ANGIOGENESIS ; GRAPHENE OXIDE ; ORAL DELIVERY ; BIOCOMPATIBILITY ; BIODISTRIBUTION ; NANOPARTICLES ; GROWTH
资助项目National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; Shanghai program[12nm0501300]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000334819800016
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277105]  
专题药物制剂研究中心
通讯作者Li, Yaping
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zhiwen,Niu, Baohua,Chen, Jian,et al. The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer[J]. BIOMATERIALS,2014,35(15):4565-4572.
APA Zhang, Zhiwen.,Niu, Baohua.,Chen, Jian.,He, Xinyu.,Bao, Xiaoyue.,...&Li, Yaping.(2014).The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer.BIOMATERIALS,35(15),4565-4572.
MLA Zhang, Zhiwen,et al."The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer".BIOMATERIALS 35.15(2014):4565-4572.

入库方式： OAI收割

来源：上海药物研究所

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