Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells
文献类型：期刊论文
| 作者 | Zhang, Xinxin1 ; Li, Feifei1; Guo, Shiyan1; Chen, Xi2; Wang, Xiaoli1; Li, Juan2; Gan, Yong1
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014-04 |
| 卷号 | 35期号:11页码:3650-3665 |
| 关键词 | Multidrug resistance Mesoporous silica nanoparticle Triggered release Irinotecan Breast cancer resistance protein |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2014.01.013 |
| 文献子类 | Article |
| 英文摘要 | Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. A polymer-lipid supported mesoporous silica nanoparticle (PLS-MSNs) is described here to facilitate intracellular delivery of anticancer drug and enhance the antitumor efficacy against MDR breast cancer cells. By coating MSNs with a synthetic dual-functional polymer-lipid material P123-DOPE, the supported membrane acted as an intact barrier against the escape of encapsulated drugs before reaching the target cells, leading to depolymerization and triggered storm release of loaded irinotecan (CPT-11) in acidic endosomal pH of tumor cells. In addition, P123-DOPE can inhibit breast cancer resistance protein (BCPR) mediated CPT-11 efflux in drug resistant MCF-7/BCRP breast cancer cells, thus acting as a "door blocker". Compared to free CPT-11, PLS-MSNs resulted in a maximum increase in the intracellular CPT-11 concentration (12.9-fold), had 7.1-fold higher cytotoxicity and processed a stronger cell cycle arrest in MCF-7/BCRP cells. Moreover, CPT-11 loaded PLS-MSNs showed high therapeutic performance and low toxicity in BALB/c nude mice bearing drug resistant breast tumors, with an inhibition rate of 81.2% compared to free CPT-11 treatment group. The reported PLS-MSNs provide promising applicability in future preclinical and clinical MDR cancer treatment. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BREAST-CANCER ; DRUG-RESISTANCE ; PROTEIN EXPRESSION ; CELLULAR UPTAKE ; BLOCK-COPOLYMERS ; PHASE-II ; DELIVERY ; TRANSPORTER ; CARCINOMA ; PARTICLES |
| 资助项目 | National Natural Science Foundation of China[30901865] ; Natural Science Foundation of Hebei Province of China[C2011319010] ; National Key Technology Research and Development Program of China[2012ZX09301001-001] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000332500700017 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277145]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Sch Pharmaceut, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xinxin,Li, Feifei,Guo, Shiyan,et al. Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells[J]. BIOMATERIALS,2014,35(11):3650-3665. |
| APA | Zhang, Xinxin.,Li, Feifei.,Guo, Shiyan.,Chen, Xi.,Wang, Xiaoli.,...&Gan, Yong.(2014).Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells.BIOMATERIALS,35(11),3650-3665. |
| MLA | Zhang, Xinxin,et al."Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells".BIOMATERIALS 35.11(2014):3650-3665. |
入库方式： OAI收割
来源：上海药物研究所
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