中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram

文献类型：期刊论文

作者Duan, Xiaopin1,2; Xiao, Jisheng2; Yin, Qi2; Zhang, Zhiwen2; Yu, Haijun2; Mao, Shirui1; Li, Yaping2
刊名NANOTECHNOLOGY
出版日期2014-03-28
卷号25期号:12
关键词breast cancer targeted drug delivery micelle disulfiram metastasis
ISSN号0957-4484
DOI10.1088/0957-4484/25/12/125102
文献子类Article
英文摘要Metastasis, the main cause of cancer related deaths, remains the greatest challenge in cancer treatment. Disulfiram (DSF), which has multi-targeted anti-tumor activity, was encapsulated into redox-sensitive shell crosslinked micelles to achieve intracellular targeted delivery and finally inhibit tumor growth and metastasis. The crosslinked micelles demonstrated good stability in circulation and specifically released DSF under a reductive environment that mimicked the intracellular conditions of tumor cells. As a result, the DSF-loaded redox-sensitive shell crosslinked micelles (DCMs) dramatically inhibited cell proliferation, induced cell apoptosis and suppressed cell invasion, as well as impairing tube formation of HMEC-1 cells. In addition, the DCMs could accumulate in tumor tissue and stay there for a long time, thereby causing significant inhibition of 4T1 tumor growth and marked prevention in lung metastasis of 4T1 tumors. These results suggested that DCMs could be a promising delivery system in inhibiting the growth and metastasis of breast cancer.
WOS关键词SUPEROXIDE-DISMUTASE PLAYS ; HUMAN-MELANOMA CELLS ; BREAST-CANCER CELLS ; ANTIALCOHOLISM DRUG ; PROTEASOME ACTIVITY ; IN-VITRO ; ANGIOGENESIS ; DELIVERY ; COPPER ; AGENT
资助项目National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; Shanghai Elitist Program[12nm0501300]
WOS研究方向Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000332669300004
出版者IOP PUBLISHING LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277150]  
专题药物制剂研究中心
通讯作者Duan, Xiaopin
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Duan, Xiaopin,Xiao, Jisheng,Yin, Qi,et al. Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram[J]. NANOTECHNOLOGY,2014,25(12).
APA Duan, Xiaopin.,Xiao, Jisheng.,Yin, Qi.,Zhang, Zhiwen.,Yu, Haijun.,...&Li, Yaping.(2014).Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram.NANOTECHNOLOGY,25(12).
MLA Duan, Xiaopin,et al."Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram".NANOTECHNOLOGY 25.12(2014).

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。