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Doxorubicin Conjugate of Poly( Ethylene Glycol)- Block Polyphosphoester for Cancer Therapy

文献类型：期刊论文

作者Sun, Chun-Yang1,2; Dou, Shuang1,2; Du, Jin-Zhi1,2; Yang, Xian-Zhu1,2; Li, Ya-Ping3; Wang, Jun1,2
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2014-02
卷号3期号:2页码:261-272
关键词biodegradable polymers cancer therapy drug conjugates nanomedicine polyphosphoesters
ISSN号2192-2640
DOI10.1002/adhm.201300091
文献子类Article
英文摘要Polyphosphoesters with repeating phosphoester linkages in the backbone can be easily functionalized, are biodegradable and potentially biocompatible, and may be potential candidates as polymer carriers of drug conjugates. Here, the efficacy of a polyphosphoester drug conjugate as an anticancer agent in vivo is assessed for the first time. With controlled synthesis, doxorubicin conjugated to poly(ethylene glycol)-block-polyphosphoester (PPEH-DOX) via labile hydrazone bonds form spherical nanoparticles in aqueous solution with an average diameter of approximate to 60 nm. These nanoparticles are effectively internalized by MDA-MB-231 breast cancer cells and release the conjugated doxorubicin in response to the intracellular pH of endosomes and lysosomes, resulting in significant antiproliferative activity in cancer cells. Compared with free doxorubicin injection, PPEH-DOX injection exhibits much longer circulation behavior in the plasma of mice and leads to enhanced drug accumulation in tumor cells. In an MDA-MB-231 xenograft murine model, inhibition of tumor growth with systemic delivery of PPEH-DOX nanoparticles is more pronounced compared with free doxorubicin injection, suggesting the potential of polyphosphoesters as carriers of drug conjugates in cancer therapy.
WOS关键词INCORPORATING MICELLAR NANOPARTICLE ; INTRACELLULAR DRUG-DELIVERY ; MACROMOLECULAR THERAPEUTICS ; MULTIDRUG-RESISTANCE ; POLYMERIC MICELLES ; SIRNA DELIVERY ; PHASE-I ; COPOLYMER ; TUMOR ; PH
资助项目National Basic Research Program of China (973 Programs)[2010CB934001] ; National Basic Research Program of China (973 Programs)[2013CB933900] ; National Natural Science Foundation of China[51125012] ; National Natural Science Foundation of China[51203145] ; Fundamental Research Funds for the Central Universities[WK2070000008] ; State Key Laboratory of Supramolecular Structure and Materials[SKLSSM201301]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000331949000013
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/277197]  
专题药物制剂研究中心
通讯作者Wang, Jun
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China;
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Chun-Yang,Dou, Shuang,Du, Jin-Zhi,et al. Doxorubicin Conjugate of Poly( Ethylene Glycol)- Block Polyphosphoester for Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2014,3(2):261-272.
APA Sun, Chun-Yang,Dou, Shuang,Du, Jin-Zhi,Yang, Xian-Zhu,Li, Ya-Ping,&Wang, Jun.(2014).Doxorubicin Conjugate of Poly( Ethylene Glycol)- Block Polyphosphoester for Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,3(2),261-272.
MLA Sun, Chun-Yang,et al."Doxorubicin Conjugate of Poly( Ethylene Glycol)- Block Polyphosphoester for Cancer Therapy".ADVANCED HEALTHCARE MATERIALS 3.2(2014):261-272.

入库方式： OAI收割

来源：上海药物研究所

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