CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery
文献类型：期刊论文
| 作者 | Wang, Zhao1; Chen, Yingzhi1; Liu, Ergang1,2; Gong, Junbo2; Shin, Meong Cheol3; Huang, Yongzhuo1
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| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 21期号:11页码:1129-1136 |
| 关键词 | Cell-penetrating peptide noncovalent nose-to-brain delivery percutaneous delivery protein delivery TAT |
| ISSN号 | 0929-8665 |
| DOI | 10.2174/0929866521666140807121903 |
| 文献子类 | Article |
| 英文摘要 | Macromolecular drugs (e.g., proteins and nucleic acids) are highly environmentally liable and unstable, and their administration is strictly limited to injection. Moreover, a vast majority of macromolecules are cell membrane-impermeable, and it is a critical issue to enhance the cellular uptake efficiency for improving the treatment outcomes. Cell-penetrating peptide (CPP)-assisted strategy is promising for effective macromolecular delivery. As a case in point, CPP-mediated protein delivery has been considered as a revolutionary breakthrough. With aid of CPP, virtually all proteins can become cell-permeable. Generally, CPP-protein delivery works in a covalent delivery pattern, by which CPP and its cargo are linked via covalent bond. Recently, noncovalent delivery has also attracted attention for its potential application for protein delivery. In the presented work, the noncovalent pattern was demonstrated for its feasibility in percutaneous and nose-to-brain delivery with TAT/GFP as model drug, in comparison with the covalent method. Noncovalent CPP/protein delivery and its noninvasive application may provide a facile method for protein therapy. |
| WOS关键词 | CELL-PENETRATING PEPTIDES ; HUMAN IMMUNODEFICIENCY VIRUS ; DRUG-DELIVERY ; GENE DELIVERY ; PLANT-CELLS ; HIV-1 TAT ; IN-VIVO ; INTRACELLULAR DELIVERY ; TRANSDUCTION DOMAIN ; HEPARAN-SULFATE |
| 资助项目 | National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2014CB931902] ; NSFC of China[81422048] ; NSFC of China[81172996] ; NSFC of China[81373357] ; Shanghai Pu-jiang Scholar Program[11PJ1411800] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000343235900005 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277263]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China; 3.Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Wang, Zhao,Chen, Yingzhi,Liu, Ergang,et al. CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery[J]. PROTEIN AND PEPTIDE LETTERS,2014,21(11):1129-1136. |
| APA | Wang, Zhao,Chen, Yingzhi,Liu, Ergang,Gong, Junbo,Shin, Meong Cheol,&Huang, Yongzhuo.(2014).CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery.PROTEIN AND PEPTIDE LETTERS,21(11),1129-1136. |
| MLA | Wang, Zhao,et al."CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery".PROTEIN AND PEPTIDE LETTERS 21.11(2014):1129-1136. |
入库方式： OAI收割
来源：上海药物研究所
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