Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs
文献类型：期刊论文
| 作者 | Tan, Jiao2; Cheong, Heesun1; Park, Yoon Shin3; Kim, Hangun4; Zhang, Meng2; Moon, Cheol4; Huang, Yongzhuo2
|
| 刊名 | CURRENT PHARMACEUTICAL BIOTECHNOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 15期号:3页码:231-239 |
| 关键词 | Biomacromolecules cell-penetrating peptide intranasal delivery non-invasive delivery percutaneous delivery topical administration |
| ISSN号 | 1389-2010 |
| DOI | 10.2174/1389201015666140617094320 |
| 文献子类 | Article |
| 英文摘要 | Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs. |
| WOS关键词 | HUMAN IMMUNODEFICIENCY VIRUS ; PROTEIN TRANSDUCTION DOMAIN ; SMALL INTERFERING RNA ; INTRACELLULAR DELIVERY ; FUNCTIONAL PEPTIDES ; INTRANASAL DELIVERY ; NASAL ABSORPTION ; MAMMALIAN-CELLS ; LINKED POLYMERS ; NUCLEIC-ACIDS |
| 资助项目 | National Basic Research Program of China (973 Program)[2014CB931900] ; National Basic Research Program of China (973 Program)[2013CB932503] ; NSFC, China[81172996] ; NSFC, China[81373357] ; Sunchon National University Research Fund - Suncheon Research Center for Natural Medicines[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000340715300006 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277272]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Moon, Cheol |
| 作者单位 | 1.Natl Canc Ctr, Res Inst, Goyang 410769, Gyeonggi Do, South Korea; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Ewha Womans Univ, Sch Med, Dept Mol Med, Global Top Res Program 5, Seoul 158710, South Korea; 4.Sunchon Natl Univ, Coll Pharm, Sunchon 540950, Jeonnam, South Korea |
| 推荐引用方式 GB/T 7714 | Tan, Jiao,Cheong, Heesun,Park, Yoon Shin,et al. Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2014,15(3):231-239. |
| APA | Tan, Jiao.,Cheong, Heesun.,Park, Yoon Shin.,Kim, Hangun.,Zhang, Meng.,...&Huang, Yongzhuo.(2014).Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,15(3),231-239. |
| MLA | Tan, Jiao,et al."Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 15.3(2014):231-239. |
入库方式： OAI收割
来源：上海药物研究所
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