Application of Precipitation Methods for the Production of Water-insoluble Drug Nanocrystals: Production Techniques and Stability of Nanocrystals
文献类型：期刊论文
| 作者 | Xia, Dengning1,2; Gan, Yong2 ; Cui, Fude1
|
| 刊名 | CURRENT PHARMACEUTICAL DESIGN
 |
| 出版日期 | 2014-01 |
| 卷号 | 20期号:3页码:408-435 |
| 关键词 | Water insoluble drug nanocrystals anti-solvent precipitation stability crystal grow and nucleation stabilizer flash precipitation supercritical anti-solvent |
| ISSN号 | 1381-6128 |
| DOI | 10.2174/13816128113199990397 |
| 文献子类 | Article |
| 英文摘要 | This review focuses on using precipitation (bottom-up) method to produce water-insoluble drug nanocrystals, and the stability issues of nanocrystals. The precipitation techniques for production of ultra-fine particles have been widely researched for last few decades. In these techniques, precipitation of solute is achieved by addition of a non-solvent for solute called anti-solvent to decrease the solvent power for the solute dissolved in a solution. The anti-solvent can be water, organic solvents or supercritical fluids. In this paper, efforts have been made to review the precipitation techniques involving the anti-solvent precipitation by simple mixing, impinging jet mixing, multi-inlet vortex mixing, the using of high-gravity, ultrasonic waves and supercritical fluids. The key to the success of yielding stable nanocrystals in these techniques is to control the nucleation kinetics and particle growth through mixing during precipitation based on crystallization theories. The stability issues of the nanocrystals, such as sedimentation, Ostwald ripening, agglomeration and cementing of crystals, change of crystalline state, and the approaches to stabilizing nanocrystals are also discussed in detail. |
| WOS关键词 | SUPERCRITICAL ANTISOLVENT PRECIPITATION ; POORLY SOLUBLE DRUGS ; CONFINED IMPINGING-JETS ; ENHANCED MASS-TRANSFER ; CEFUROXIME AXETIL NANOPARTICLES ; GRAVITY REACTIVE PRECIPITATION ; COMPUTATIONAL FLUID-DYNAMICS ; HIGH-PRESSURE HOMOGENIZATION ; RESIDENCE TIME DISTRIBUTION ; ANTI-SOLVENT PRECIPITATION |
| 资助项目 | National Natural Science Foundation[30873182] ; National Basic Research Program of China (973 Program)[2009CB930302] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000334303800007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277297]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Cui, Fude |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Dengning,Gan, Yong,Cui, Fude. Application of Precipitation Methods for the Production of Water-insoluble Drug Nanocrystals: Production Techniques and Stability of Nanocrystals[J]. CURRENT PHARMACEUTICAL DESIGN,2014,20(3):408-435. |
| APA | Xia, Dengning,Gan, Yong,&Cui, Fude.(2014).Application of Precipitation Methods for the Production of Water-insoluble Drug Nanocrystals: Production Techniques and Stability of Nanocrystals.CURRENT PHARMACEUTICAL DESIGN,20(3),408-435. |
| MLA | Xia, Dengning,et al."Application of Precipitation Methods for the Production of Water-insoluble Drug Nanocrystals: Production Techniques and Stability of Nanocrystals".CURRENT PHARMACEUTICAL DESIGN 20.3(2014):408-435. |
入库方式： OAI收割
来源：上海药物研究所
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