Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor
文献类型：期刊论文
| 作者 | Yin, Fei1; Guo, Shiyan2; Gan, Yong2 ; Zhang, Xinxin2
|
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 9页码:1665-1675 |
| 关键词 | spray freeze-drying recombinant human epithelial growth factor liposomes skin permeability transdermal drug delivery |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S59463 |
| 文献子类 | Article |
| 英文摘要 | In this work, an ultrasonic spray freeze-drying (USFD) technique was used to -prepare a stable liposomal dry powder for transdermal delivery of recombinant human epithelial growth factor (rhEGF). Morphology, particle size, entrapment efficiency, in vitro release, and skin permeability were systematically compared between rhEGF liposomal dry powder prepared using USFD and that prepared using a conventional lyophilization process. Porous and -spherical particles with high specific area were produced under USFD conditions. USFD effectively avoided formation of ice crystals, disruption of the bilayer structure, and drug leakage during the liposome drying process, and maintained the stability of the rhEGF liposomal formulation during storage. The reconstituted rhEGF liposomes prepared from USFD powder did not show significant changes in morphology, particle size, entrapment efficiency, or in vitro release characteristics compared with those of rhEGF liposomes before drying. Moreover, the rhEGF liposomal powder prepared with USFD exhibited excellent enhanced penetration in ex vivo mouse skin compared with that for powder prepared via conventional lyophilization. The results suggest that ultrasonic USFD is a promising technique for the production of stable protein-loaded liposomal dry powder for application to the skin. |
| WOS关键词 | DRUG-DELIVERY ; ELASTIC LIPOSOMES ; MEMBRANES ; CARRIERS ; INSULIN |
| 资助项目 | National Natural Science Foundation of China[30901865] ; Natural Science Foundation of Hebei Province of China[C2011319010] ; National Key Technology Research and Development Program of China[2012ZX09301001-001] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000333522100002 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277301]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Xinxin |
| 作者单位 | 1.Liaoning Canc Hosp & Inst, Dept Pharm, Shenyang 110042, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Fei,Guo, Shiyan,Gan, Yong,et al. Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:1665-1675. |
| APA | Yin, Fei,Guo, Shiyan,Gan, Yong,&Zhang, Xinxin.(2014).Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,1665-1675. |
| MLA | Yin, Fei,et al."Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):1665-1675. |
入库方式： OAI收割
来源：上海药物研究所
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