Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway
文献类型：期刊论文
| 作者 | Xu, Marvin Xuejun5; Zhao, Linlin4; Deng, Chaoyang4; Yang, Lu4; Wang, Yang3; Guo, Tao2; Li, Lifang3; Lin, Jianping1; Zhang, Lirong5 |
| 刊名 | INTERNATIONAL JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2013-12 |
| 卷号 | 43期号:6页码:1951-1959 |
| 关键词 | curcumin Wnt signaling pathway hepatocellular carcinoma |
| ISSN号 | 1019-6439 |
| DOI | 10.3892/ijo.2013.2107 |
| 文献子类 | Article |
| 英文摘要 | Curcumin from the rhizome of Curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in G2 and modulating the wnt signaling pathway. We found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (HCC) cells in a concentration-dependent manner. We identified that curcumin interrupts wnt signaling by decreasing -catenin activity, which in turn suppresses the expression of -catenin target genes (c-myc, VEGF and cyclin D1). Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional -catenin destruction complex in normal cells. This results in -catenin being unable to accumulate in the nucleus, depriving the protein of its ability to bind with lymphoid enhancer factor/T cell-specific transcription factor (Lef/Tcf) and repressing its activation of target gene transcription. This may be one mechanism through which curcumin inhibits proliferation and induces apoptosis of HCC cells. |
| WOS关键词 | BETA-CATENIN ; CANCER ; TARGET ; ACTIVATION ; DISEASE |
| 资助项目 | Tianjin Science and Technology Committee[11zckfsy07300] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000330225800025 |
| 出版者 | SPANDIDOS PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277342]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Xu, Marvin Xuejun |
| 作者单位 | 1.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 2012203, Peoples R China; 3.Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China; 4.Shanghai McAry Biomed Technol Co Ltd, Shanghai 201203, Peoples R China; 5.Zhengzhou Univ, Dept Pharmacol, Basic Med Coll, Zhengzhou 450001, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Marvin Xuejun,Zhao, Linlin,Deng, Chaoyang,et al. Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2013,43(6):1951-1959. |
| APA | Xu, Marvin Xuejun.,Zhao, Linlin.,Deng, Chaoyang.,Yang, Lu.,Wang, Yang.,...&Zhang, Lirong.(2013).Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway.INTERNATIONAL JOURNAL OF ONCOLOGY,43(6),1951-1959. |
| MLA | Xu, Marvin Xuejun,et al."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway".INTERNATIONAL JOURNAL OF ONCOLOGY 43.6(2013):1951-1959. |
入库方式： OAI收割
来源：上海药物研究所
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