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Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
文献类型：期刊论文
| 作者 | Yin, Qi ; Shen, Jianan; Zhang, Zhiwen; Yu, Haijun; Li, Yaping
|
| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2013-11-30 |
| 卷号 | 65期号:13-14页码:1699-1715 |
| 关键词 | Stimuli Responsive Drug delivery Multidrug resistance Tumor Chemotherapy |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2013.04.011 |
| 文献子类 | Review |
| 英文摘要 | Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. The new drug delivery system (DDS) provides promising approaches to reverse MDR, for which the poor cellular uptake and insufficient intracellular drug release remain rate-limiting steps for reaching the drug concentration level within the therapeutic window. Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites. In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; BREAST-CANCER CELLS ; BLOCK-COPOLYMER MICELLES ; TARGETED PHOTODYNAMIC THERAPY ; EFFICIENT GENE DELIVERY ; IN-VITRO ; GOLD NANOPARTICLES ; INTRACELLULAR DELIVERY ; POLYMERIC MICELLE ; ANTICANCER DRUG |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[81230029] ; Shanghai Science and Technology Innovation Action Plan[11nm0505900] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000328309500004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277370]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Qi,Shen, Jianan,Zhang, Zhiwen,et al. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor[J]. ADVANCED DRUG DELIVERY REVIEWS,2013,65(13-14):1699-1715. |
| APA | Yin, Qi,Shen, Jianan,Zhang, Zhiwen,Yu, Haijun,&Li, Yaping.(2013).Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor.ADVANCED DRUG DELIVERY REVIEWS,65(13-14),1699-1715. |
| MLA | Yin, Qi,et al."Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor".ADVANCED DRUG DELIVERY REVIEWS 65.13-14(2013):1699-1715. |
入库方式： OAI收割
来源：上海药物研究所
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