Nanocarriers for siRNA delivery to overcome cancer multidrug resistance
文献类型：期刊论文
| 作者 | Meng QingShuo; Yin Qi ; Li YaPing
|
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2013-11 |
| 卷号 | 58期号:33页码:4021-4030 |
| 关键词 | cationic polymers inorganic carriers liposomes multidrug resistance nanocarriers siRNA delivery |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-013-6030-9 |
| 文献子类 | Review |
| 英文摘要 | Multidrug resistance (MDR) is an extremely complexed phenomenon in tumor chemotherapy and is one of the major obstacles for successful treatment. Discovery of RNA interference (RNAi) offers a new strategy with great potential to reverse MDR. Specific genes, which contribute to the emerging of MDR, can be silenced by RNAi. However, many natural barriers have to be overcome for efficient and safe delivery of siRNA. In recent years, the various kinds of nanocarriers, such as liposomes, cationic polymers, and inorganic materials, have been developed to deliver siRNA and show good results in reversing MDR. This review mainly summarizes the barriers in siRNA delivery and recent progress in designing nanotechnology-based siRNA delivery systems to overcome tumor MDR. |
| WOS关键词 | SMALL-INTERFERING RNA ; MESOPOROUS SILICA NANOPARTICLES ; NONVIRAL GENE DELIVERY ; POLY-L-ARGININE ; IN-VIVO ; CO-DELIVERY ; DRUG-RESISTANCE ; BREAST-CANCER ; RADICAL POLYMERIZATION ; TARGETED DELIVERY |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[81270047] ; Shanghai Elitist Program[11XD1406200] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000326829500001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277394]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li YaPing |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng QingShuo,Yin Qi,Li YaPing. Nanocarriers for siRNA delivery to overcome cancer multidrug resistance[J]. CHINESE SCIENCE BULLETIN,2013,58(33):4021-4030. |
| APA | Meng QingShuo,Yin Qi,&Li YaPing.(2013).Nanocarriers for siRNA delivery to overcome cancer multidrug resistance.CHINESE SCIENCE BULLETIN,58(33),4021-4030. |
| MLA | Meng QingShuo,et al."Nanocarriers for siRNA delivery to overcome cancer multidrug resistance".CHINESE SCIENCE BULLETIN 58.33(2013):4021-4030. |
入库方式： OAI收割
来源：上海药物研究所
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