Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery
文献类型：期刊论文
| 作者 | Huang, Yongzhuo3,4,5 ; Jiang, Yifan5; Wang, Huiyuan5; Wang, Jianxin3,4; Shin, Meong Cheol2; Byun, Youngro6; He, Huining1; Liang, Yanqin1; Yang, Victor C.1,2,6
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| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2013-10-15 |
| 卷号 | 65期号:10页码:1299-1315 |
| ISSN号 | 0169-409X |
| 关键词 | Cell-penetrating peptide (CPP) Drug delivery system Prodrug Targeted delivery In vivo |
| DOI | 10.1016/j.addr.2012.11.007 |
| 文献子类 | Review |
| 英文摘要 | Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often specifically termed as "the Trojan horse approach", has become the "holy grail" in achieving effective delivery of macromolecular compounds such as proteins, DNA, siRNAs, and drug carriers. It is characterized by the unique cell(or receptor-), temperature-, and payload-independent mechanisms, therefore offering potent means to improve poor cellular uptake of a variety of macromolecular drugs. Nevertheless, this "Trojan horse" approach also acts like a double-edged sword, causing serious safety and toxicity concerns to normal tissues or organs for in vivo application, due to lack of target selectivity of the powerful cell penetrating activity. To overcome this problem of potent yet non-selective penetration vs. targeting delivery, a number of "smart" strategies have been developed in recent years, including controllable CPP-based drug delivery systems based on various stimuli-responsive mechanisms. This review article provides a fundamental understanding of these smart systems, as well as a discussion of their real-time in vivo applicability. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | MULTIFUNCTIONAL POLYMERIC MICELLE ; HUMAN IMMUNODEFICIENCY VIRUS ; IN-VIVO ; INTRACELLULAR DELIVERY ; TAT-PEPTIDE ; PROTEIN TRANSDUCTION ; PEGYLATED LIPOSOMES ; GENE DELIVERY ; PHARMACEUTICAL NANOCARRIERS ; QUANTUM DOTS |
| 资助项目 | NSFC, China[91029743] ; NSFC, China[81172996] ; National Basic Research Program of China (973 Program)[2013CB932503] ; Shanghai Pu-jiang Scholar Program[00000000] ; School of Pharmacy, Fudan University[00000000] ; Key Lab of Smart Drug Delivery (Fudan University)[00000000] ; MOE PLA, China[SDD2011-02] ; NIH[CA114612] ; World Class University (WCU) project of the MEST[R31-2008-000-10103-01] ; NRF of South Korea[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000326560900003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277420]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China 2.Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA; 3.MOE PLA, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 6.Seoul Natl Univ, Dept Mol Med & Biopharmaceut, Seoul, South Korea; |
| 推荐引用方式 GB/T 7714 | Huang, Yongzhuo,Jiang, Yifan,Wang, Huiyuan,et al. Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery[J]. ADVANCED DRUG DELIVERY REVIEWS,2013,65(10):1299-1315. |
| APA | Huang, Yongzhuo.,Jiang, Yifan.,Wang, Huiyuan.,Wang, Jianxin.,Shin, Meong Cheol.,...&Yang, Victor C..(2013).Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery.ADVANCED DRUG DELIVERY REVIEWS,65(10),1299-1315. |
| MLA | Huang, Yongzhuo,et al."Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery".ADVANCED DRUG DELIVERY REVIEWS 65.10(2013):1299-1315. |
入库方式： OAI收割
来源：上海药物研究所
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