Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System
文献类型：期刊论文
| 作者 | He, Huining3,6; David, Allan2; Chertok, Beata2; Cole, Adam2; Lee, Kyuri2; Zhang, Jian2; Wang, Jianxin1,5,7; Huang, Yongzhuo1,4,5,7 ; Yang, Victor C.2,6
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| 刊名 | PHARMACEUTICAL RESEARCH
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| 出版日期 | 2013-10 |
| 卷号 | 30期号:10页码:2445-2458 |
| 关键词 | brain tumor/cancer cell-penetrating peptide magnetic nanoparticles theranostic system tumor imaging and therapy |
| ISSN号 | 0724-8741 |
| DOI | 10.1007/s11095-013-0982-y |
| 文献子类 | Review |
| 英文摘要 | In this review, we discussed the establishment of a so-called "theranostic" system by instituting the basic principles including the use of: [1] magnetic iron oxide nanoparticles (MION)-based drug carrier; [2] intra-arterial (I.A.) magnetic targeting; [3] macromolecular drugs with unmatched therapeutic potency and a repetitive reaction mechanism; [4] cell-penetrating peptide-mediated cellular drug uptake; and [5] heparin/protamine-regulated prodrug protection and tumor-specific drug re-activation into one single drug delivery system to overcome all possible obstacles, thereby achieving a potentially non-invasive, magnetic resonance imaging-guided, clinically enabled yet minimally toxic brain tumor drug therapy. By applying a topography-optimized I.A. magnetic targeting to dodge rapid organ clearance of the carrier during its first passage into the circulation, tumor capture of MION was enriched by > 350 folds over that by conventional passive enhanced permeability and retention targeting. By adopting the prodrug strategy, we observed by far the first experimental success in a rat model of delivering micro-gram quantity of the large beta-galactosidase model protein selectively into a brain tumor but not to the ipsi- or contra-lateral normal brain regions. With the therapeutic regimens of most toxin/siRNA drugs to fully (> 99.9%) eradicate a tumor being in the nano-molar range, the prospects of reaching this threshold become practically accomplishable. |
| WOS关键词 | MOLECULAR-WEIGHT PROTAMINE ; IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; BRAIN-TUMORS ; TARGETED NANOPARTICLES ; HEPARIN ANTAGONIST ; RADIATION-INJURY ; PROTEIN DELIVERY ; MALIGNANT GLIOMA ; CANCER-TREATMENT |
| 资助项目 | National Institutes of Health[CA114612] ; National Institutes of Health[NS066945] ; Hartwell Foundation Biomedical Research Award[00000000] ; World Class University (WCU) project of South Korea[R31-2008-000-10103-01] ; National Key Basic Research Program of China, School of Pharmacy, Fudan University[2013CB932502] ; Key Lab of Smart Drug Delivery (Fudan University)[00000000] ; MOE[00000000] ; PLA, China[SDD2011-02] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000324074800003 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277448]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yang, Victor C. |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200433, Peoples R China; 2.Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA; 3.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.PLA, Shanghai 201203, Peoples R China; 6.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China 7.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | He, Huining,David, Allan,Chertok, Beata,et al. Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System[J]. PHARMACEUTICAL RESEARCH,2013,30(10):2445-2458. |
| APA | He, Huining.,David, Allan.,Chertok, Beata.,Cole, Adam.,Lee, Kyuri.,...&Yang, Victor C..(2013).Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System.PHARMACEUTICAL RESEARCH,30(10),2445-2458. |
| MLA | He, Huining,et al."Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System".PHARMACEUTICAL RESEARCH 30.10(2013):2445-2458. |
入库方式： OAI收割
来源：上海药物研究所
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