Cell-penetrating albumin conjugates for enhanced doxorubicin delivery
文献类型：期刊论文
| 作者 | Guo, Qianqian1,5; Wang, Huiyuan1 ; Zhao, Yongxing5; Wang, Huixin1,5; Zeng, Feng1,4; Hua, Haiying5; Xu, Qin4; Huang, Yongzhuo1,2,3
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| 刊名 | POLYMER CHEMISTRY
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| 出版日期 | 2013-09-17 |
| 卷号 | 4期号:17页码:4584-4587 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c3py00742a |
| 文献子类 | Article |
| 英文摘要 | Albumin-based drug delivery has been demonstrated to be useful for achieving improved cancer therapy, largely due to its passive target toward tumor via the enhanced permeability and retention effect and the increased demand for albumin by tumor cells as source of energy and amino acids. However, albumin lacks not only the active mechanism to overcome the cell membrane barrier, but also the ability to penetrate into tumor tissues. Herein, a cell-penetrating albumin-based delivery strategy was developed, in which a cell-penetrating peptide was chemically conjugated to albumin in order to enhance the efficiency of intracellular delivery and tumor penetration. Doxorubicin (DOX) molecules were loaded into the carrier via cleavable disulfide bonds, which are responsive to the highly reducing environment in the cytosol of tumor cells, thus archiving prodrug-type targeted drug release. The cell-penetrating albumin-DOX conjugates displayed significantly higher antitumor activity than DOX. More interestingly, the conjugates also efficiently killed the drug-resistant tumor cells, in sharp contrast to the ineffective DOX. The studies with human xenograft tumors in nude mice further demonstrated the enhanced antitumor efficacy and reduced side effects of the cell-penetrating albumin-assisted DOX delivery strategy, indicating the promise of this delivery system. |
| WOS关键词 | MOLECULAR-WEIGHT PROTAMINE ; SERUM-ALBUMIN ; DRUG-RESISTANCE ; CANCER ; NANOPARTICLES ; TOXICITY ; EFFICACY ; CARRIER ; DESIGN ; LMWP |
| 资助项目 | National Basic Research Program of China (973 Program)[2013CB932503] ; NSFC of China[91029743] ; NSFC of China[81172996] ; Shanghai Pu-jiang Scholar Program[11PJ1411800] ; School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), MOE PLA[SDD2011-02] ; Chinese Postdoctoral Science Foundation[2012M510097] ; Chinese Postdoctoral Science Foundation[2013T60478] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000323361300007 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277458]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, PLA, Shanghai 201203, Peoples R China 3.Fudan Univ, Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 4.Guangzhou Univ TCM, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China; 5.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Guo, Qianqian,Wang, Huiyuan,Zhao, Yongxing,et al. Cell-penetrating albumin conjugates for enhanced doxorubicin delivery[J]. POLYMER CHEMISTRY,2013,4(17):4584-4587. |
| APA | Guo, Qianqian.,Wang, Huiyuan.,Zhao, Yongxing.,Wang, Huixin.,Zeng, Feng.,...&Huang, Yongzhuo.(2013).Cell-penetrating albumin conjugates for enhanced doxorubicin delivery.POLYMER CHEMISTRY,4(17),4584-4587. |
| MLA | Guo, Qianqian,et al."Cell-penetrating albumin conjugates for enhanced doxorubicin delivery".POLYMER CHEMISTRY 4.17(2013):4584-4587. |
入库方式： OAI收割
来源：上海药物研究所
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