Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions
文献类型：期刊论文
| 作者 | Yang, Rui2; Zhang, Xinxin1 ; Li, Feifei1; Ding, Lixia2; Li, Bo2; Sun, Huimin2; Gan, Yong1
|
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2013-09-05 |
| 卷号 | 436页码:434-442 |
| 关键词 | Emulsions Stability Lipolysis Pluronic P123 Dioleoylphosphatidylcholine Dioleoylphosphatidylethanolamine |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2013.07.022 |
| 文献子类 | Article |
| 英文摘要 | Understanding the factors that control the stability at the oil-water interface continues to be a major focus to optimize the formulation of intravenous emulsion. In this study, we investigated how phospholipids and nonionic polymeric surfactants influence the emulsifying capacity, stability, and lipolysis kinetics of emulsions under physiological conditions. 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and Pluronic P123, either alone or in combination were used as emulsifiers to prepare emulsions. Then, in vitro methods were applied to study the emulsifying capacity during the manufacturing process, and emulsion stability under both heat treatment and intravenous lipolysis conditions. Our results showed that an emulsifier blend with DOPC, DOPE, and Pluronic P123 resulted in a higher surface activity and produced smaller and more uniform droplet sizes in comparison to the use of DOPC alone. In addition, mixed emulsifier-stabilized emulsions showed more stable droplet sizes and surface tensions under heating and lipolysis treatments, as well as decreased lipolysis rates under physiological conditions. The reason for this seems to be the high transition temperature and steric hindrance produced by DOPE and Pluronic P123. Mixed emulsifier-stabilized emulsions resulted in increased activation energy values. A better understanding of the relationship between the surfactant and oil droplets may be applied in the development of novel strategies to rationally design submicron emulsions as lipophilic drug carriers. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | SUBMICRON EMULSIONS ; CHALLENGES ; LIPOLYSIS ; SYSTEMS ; CARRIER |
| 资助项目 | National Science & Technology Major Project, "Key New Drug Creation and Manufacturing Program"[2011ZX09303-001] ; National Science & Technology Major Project, "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Natural Science Foundation of Hebei Province of China[C2011319010] ; National Natural Science Foundation of China[30901865] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000326416900056 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277466]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Sun, Huimin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Rui,Zhang, Xinxin,Li, Feifei,et al. Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2013,436:434-442. |
| APA | Yang, Rui.,Zhang, Xinxin.,Li, Feifei.,Ding, Lixia.,Li, Bo.,...&Gan, Yong.(2013).Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,436,434-442. |
| MLA | Yang, Rui,et al."Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 436(2013):434-442. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。