Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets
文献类型：期刊论文
| 作者 | Yin, Xianzhen2,3; Li, Haiyan3 ; Liu, Ruihao3; Chen, Jing3; Ji, Junqiu1; Chen, Jun1; Shao, Qun2; Xiao, Tiqiao4; York, Peter2; He, You4
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| 刊名 | JOURNAL OF PHARMACY AND PHARMACOLOGY
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| 出版日期 | 2013-07 |
| 卷号 | 65期号:7页码:953-959 |
| 关键词 | 3D fractal analysis 3D reconstruction drug release kinetics osmotic drug delivery synchrotron radiation X-ray computed microtomography |
| ISSN号 | 0022-3573 |
| DOI | 10.1111/jphp.12056 |
| 文献子类 | Article |
| 英文摘要 | Objectives To calculate the fractal dimension values of felodipine osmotic pump tablets during drug dissolution and to characterize the mechanism of the controlled drug release kinetics through three-dimensional fractal data. Methods Three-dimensional fractal values of volume (Df,volume) and surface (Df,surface) of the tablet core were calculated based on the box counting method. Key findings During the process of release of felodipine, both Df,volume and Df,surface were within the range of 2-3 and then changed markedly after a period of 3.0 h release, corresponding to extensive changes in entire shape, interior porous channels and surface structure of the tablet core. The curve of Df,volume mirrored that for tablet volume, however the curve of Df,surface was quite different from that of the surface area. Results showed that values of Df,surface correlated well with the drug release rate. Df,surface was found to be an efficient fractal parameter that could be used to characterize the complex changes to the tablet core that take place during drug release. Conclusions The fractal dimension can be used as a quantitative indicator reflecting the drug release performance and be regarded as a key indicator for the quality control of oral controlled drug delivery systems. |
| WOS关键词 | DOSAGE FORMS ; IN-VITRO ; DISSOLUTION ; PARTICLES ; DIMENSION ; MATRICES ; TOOL ; MRI |
| 资助项目 | National Science and Technology Major Project of the Ministry of Science and Technology of China[2012ZX09301001-001] ; National Natural Science Foundation of China[81273453] ; National Natural Science Foundation of China[81173556] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000320063800002 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277574]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Hefei Lifeon Medicat Grp, Hefei, Peoples R China; 2.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201204, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yin, Xianzhen,Li, Haiyan,Liu, Ruihao,et al. Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2013,65(7):953-959. |
| APA | Yin, Xianzhen.,Li, Haiyan.,Liu, Ruihao.,Chen, Jing.,Ji, Junqiu.,...&Zhang, Jiwen.(2013).Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets.JOURNAL OF PHARMACY AND PHARMACOLOGY,65(7),953-959. |
| MLA | Yin, Xianzhen,et al."Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets".JOURNAL OF PHARMACY AND PHARMACOLOGY 65.7(2013):953-959. |
入库方式： OAI收割
来源：上海药物研究所
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