Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine
文献类型：期刊论文
| 作者 | Zhang, Zhiwen2 ; Liu, Zeying1; Ma, Li2; Jiang, Shijun1; Wang, Yixin2; Yu, Haijun2; Yin, Qi2; Cui, Jingbin1; Li, Yaping2
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| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2013-06 |
| 卷号 | 10期号:6页码:2426-2434 |
| 关键词 | stearylamine multidrug resistance self-assembly nanocarrier teniposide mitochondria |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/mp400039j |
| 文献子类 | Article |
| 英文摘要 | Multidrug resistance (MDR) remains one of the major challenges for successful chemotherapy. Herein, we tried to develope a mitochondria targeted teniposide loaded self assembled nanocarrier based on stearylamine (SA-TSN) to reverse MDR of breast cancer. SA-TSN was nanometer-sized spherical particles (31.59 +/- 3.43 nm) with a high, encapsulation efficiency (99.25 +/- 0.21%). The MDR in MCF-7/ADR cells was obviously reduced by SA-TSN, which mainly attributed to the markedly reduced expression of P-gp, increased percentages in G2 phase, selectively accumulation in mitochondria, decrease of mitochondrial membrane potential, and greatly improved apoptosis. The plasma concentration of teniposide was greatly improved by SA-TSN, and the intravenously administered SA-TSN could accumulate in the tumor site and penetrate into the inner site of tumor in MCF-7/ADR induced xenografts. In particular, the in vivo tumor inhibitory efficacy of SA-TSN in MCF-7/ADR induced models was more effective than that of teniposide loaded self-assembled nanocarrier without stearylamine (TSN) and teniposide solution (TS), which verified the effectiveness of SA-TSN in reversal of MDR. Thereby, SA-TSN has potential to circumvent the MDR for the chemotherapy of breast cancer. |
| WOS关键词 | CANCER DRUG-RESISTANCE ; POLYMERIC MICELLES ; INDUCE APOPTOSIS ; LIPOSOMES ; TENIPOSIDE ; MECHANISMS ; PACLITAXEL ; PATHWAY ; CELLS ; CHEMOTHERAPY |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[81270047] ; Shanghai Program[11 nm0505900] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000320015600033 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277598]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Liu, Zeying,Ma, Li,et al. Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine[J]. MOLECULAR PHARMACEUTICS,2013,10(6):2426-2434. |
| APA | Zhang, Zhiwen.,Liu, Zeying.,Ma, Li.,Jiang, Shijun.,Wang, Yixin.,...&Li, Yaping.(2013).Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine.MOLECULAR PHARMACEUTICS,10(6),2426-2434. |
| MLA | Zhang, Zhiwen,et al."Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine".MOLECULAR PHARMACEUTICS 10.6(2013):2426-2434. |
入库方式： OAI收割
来源：上海药物研究所
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