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Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking
文献类型：期刊论文
| 作者 | Duan, Xiaopin1,2; Li, Yaping1
|
| 刊名 | SMALL
 |
| 出版日期 | 2013-05-27 |
| 卷号 | 9期号:9-10页码:1521-1532 |
| 关键词 | nanoparticles circulation internalization physicochemical characteristics tumor therapy |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201201390 |
| 文献子类 | Review |
| 英文摘要 | Nanoparticles have many potential applications in tumor therapy. Systemically administered nanoparticles should remain in circulation for a long time to increase their accumulation in targeted tissues before being cleared by the reticuloendothelial system, and be effectively internalized by the targeted cells, which can be influenced significantly by the physicochemical characteristics of nanoparticles, such as particle size, surface properties, and particle shape. This review highlights the impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; MESOPOROUS SILICA NANOPARTICLES ; MULTIFUNCTIONAL POLYMERIC MICELLE ; BLOCK-COPOLYMER MICELLES ; MESENCHYMAL STEM-CELLS ; HUMAN TUMOR XENOGRAFT ; IN-VIVO BEHAVIOR ; PEG CHAIN-LENGTH ; PARTICLE-SIZE ; DRUG-DELIVERY |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2009CB930304] ; National Natural Science Foundation of China[30925041] ; Shanghai Elitist Program[11XD1406200] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000319076000009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277611]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 200031, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Xiaopin,Li, Yaping. Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking[J]. SMALL,2013,9(9-10):1521-1532. |
| APA | Duan, Xiaopin,&Li, Yaping.(2013).Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking.SMALL,9(9-10),1521-1532. |
| MLA | Duan, Xiaopin,et al."Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking".SMALL 9.9-10(2013):1521-1532. |
入库方式： OAI收割
来源：上海药物研究所
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