Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery
文献类型：期刊论文
| 作者 | Yan, Lu1,4; Wang, Huiyuan1 ; Jiang, Yifan1; Liu, Jinhua1; Wang, Zhao1; Yang, Yongxin1; Huang, Shengwu4; Huang, Yongzhuo1,2,3
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| 刊名 | MACROMOLECULAR RESEARCH
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| 出版日期 | 2013-04 |
| 卷号 | 21期号:4页码:435-441 |
| 关键词 | cell-penetrating peptide intranasal delivery brain target insulin PLGA nanoparticles |
| ISSN号 | 1598-5032 |
| DOI | 10.1007/s13233-013-1029-2 |
| 文献子类 | Article |
| 英文摘要 | Macromolecular drugs become an essential part in neuroprotective treatment. However, the nature of ineffective delivery crossing the blood brain barrier (BBB) renders those macromolecules undruggable for clinical practice. Recently, brain target via intranasal delivery have provided a promising solution to circumventing the BBB. Despite the direct route from nose to brain (i.e. olfactory pathway), there still are big challenges for large compounds like proteins to overcome the multiple delivery barriers such as nasal mucosa penetration, intracellular transport along the olfactory neuron, and diffusion across the heterogeneous brain compartments. Herein presented is an intranasal strategy mediated by cell-penetrating peptide modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the delivery of insulin to the brain, a potent therapeutic against Alzheimer's disease. The results revealed that the cell-penetrating peptide can potentially deliver insulin into brain via the nasal route, showing a total brain delivery efficiency of 6%. It could serve as a potential treatment for neurodegenerative diseases. |
| WOS关键词 | VIVO PROTEIN TRANSDUCTION ; INTRACELLULAR DELIVERY ; DRUG-DELIVERY ; LIVING CELLS ; INSULIN ; TRANSPORT ; CANCER |
| 资助项目 | National Natural Science Foundation of China (NSFC)[91029743] ; National Natural Science Foundation of China (NSFC)[81172996] ; Shanghai Pu-jiang Scholarship[00000000] ; School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education PLA, China[00000000] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000318177400016 |
| 出版者 | POLYMER SOC KOREA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277668]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai, Peoples R China; 3.PLA, Beijing, Peoples R China 4.Zhejiang Univ TCM, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yan, Lu,Wang, Huiyuan,Jiang, Yifan,et al. Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery[J]. MACROMOLECULAR RESEARCH,2013,21(4):435-441. |
| APA | Yan, Lu.,Wang, Huiyuan.,Jiang, Yifan.,Liu, Jinhua.,Wang, Zhao.,...&Huang, Yongzhuo.(2013).Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery.MACROMOLECULAR RESEARCH,21(4),435-441. |
| MLA | Yan, Lu,et al."Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery".MACROMOLECULAR RESEARCH 21.4(2013):435-441. |
入库方式： OAI收割
来源：上海药物研究所
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