Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction
文献类型：期刊论文
| 作者 | Liu, Ruihao4; Yin, Xianzhen2,4; Li, Haiyan3,4 ; Shao, Qun2; York, Peter2; He, You1; Xiao, Tiqiao1; Zhang, Jiwen4
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| 出版日期 | 2013-03-10 |
| 卷号 | 445期号:1-2页码:125-133 |
| 关键词 | Mixing Segregation Synchrotron radiation X-ray computed microtomography Three dimensional reconstruction Frequency distribution Mixing index |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2013.02.010 |
| 文献子类 | Article |
| 英文摘要 | Tomographic imaging techniques have great potential for improving understanding of the dynamics of granular materials during manufacturing, handling, and storage. In this study, the synchrotron radiation X-ray computed microtomography (SR-mu CT) was used non-invasively to monitor blend homogeneity of binary mixtures. Granular samples of microcrystalline cellulose and starch were characterized using the SR-mu CT individually. Simultaneously, particle distribution was investigated by calculating the frequency distribution of a statistic for testing sphericity. Then, the microcrystalline cellulose and starch granules were blended in a cylindrical container. Influences of the time of rotations T-R and the time of vibration TV on the mixture homogeneity were studied with the SR-mu CT and statistical evaluation. The mixing index is also adopted to evaluate the mixture homogeneity of the particle system. The results showed that mixture homogeneity is improved with increasing TR. Furthermore, segregation increased with longer TV when particles are different in size and shape. The larger starch granules of non-spherical shape have a tendency to rise to the top, while the smaller microcrystalline cellulose granules which are spherical tend to migrate to the bottom of the mixture. Therefore, we demonstrate that SR-mu CT can investigate the mixing and segregation of granular materials in three-dimensions combined with statistic method. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | PARTICLE-SIZE ; CONTENT UNIFORMITY ; TABLETS ; SOLIDS ; SPECTROSCOPY ; TOMOGRAPHY ; RELEASE |
| 资助项目 | Drug Technology Innovation and Industrialization Strategic Alliance Project of China - CSPS/ZMC Union Candidate Innovative Drug Research Project[2010ZX09401-402] ; Natural Science Foundation of China[81273453] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000315947300015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277699]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 2.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 3.State Key Lab Long Acting & Targeting Drug Delive, Yantai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Ruihao,Yin, Xianzhen,Li, Haiyan,et al. Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,445(1-2):125-133. |
| APA | Liu, Ruihao.,Yin, Xianzhen.,Li, Haiyan.,Shao, Qun.,York, Peter.,...&Zhang, Jiwen.(2013).Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction.INTERNATIONAL JOURNAL OF PHARMACEUTICS,445(1-2),125-133. |
| MLA | Liu, Ruihao,et al."Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction".INTERNATIONAL JOURNAL OF PHARMACEUTICS 445.1-2(2013):125-133. |
入库方式： OAI收割
来源：上海药物研究所
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