Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites
文献类型：期刊论文
| 作者 | He, Huining1,2,7; Ye, Junxiao7; Sheng, Jianyong4,5,6; Wang, Jianxin4,5,6; Huang, Yongzhuo3,4,5,6 ; Chen, Guanyi2; Wang, Jingkang7; Yang, Victor C.1,8
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| 刊名 | FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
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| 出版日期 | 2013-03 |
| 卷号 | 7期号:1页码:9-19 |
| 关键词 | insulin cell penetrating peptide mucoadhesive composites oral delivery |
| ISSN号 | 2095-0179 |
| DOI | 10.1007/s11705-013-1306-9 |
| 文献子类 | Review |
| 英文摘要 | Oral insulin delivery has received the most attention in insulin formulations due to its high patient compliance and, more importantly, to its potential to mimic the physiologic insulin secretion seen in non-diabetic individuals. However, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulin degradation, and the mucosal barrier that limits insulin's bioavailability. Several approaches have been actively pursued to circumvent the enzyme barrier, with some of them receiving promising results. Yet, thus far there has been no major success in overcoming the mucosal barrier, which is the main cause in undercutting insulin's oral bioavailability. In this review of our group's research, an innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptide (CPP) to overcome both enzyme and mucosal barriers is discussed, and the preliminary and convincing results to confirm the plausibility of this oral insulin delivery system are reviewed. In vitro studies demonstrated that the CPP-insulin conjugates could facilitate cellular uptake of insulin while keeping insulin's biologic functions intact. It was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a cell translocation potency equivalent to that of the widely studied TAT. The mucoadhesive properties of the produced silica-chitosan composites could be controlled by varying both the pH and composition; the composite consisting of chitosan (25 wt-%) and silica (75 wt-%) exhibited the greatest mucoadhesion at gastric pH. Furthermore, drug release from the composite network could also be regulated by altering the chitosan content. Overall, the universal applicability of those technologies could lead to development of a generic platform for oral delivery of many other bioactive compounds, especially for peptide or protein drugs which inevitably encounter the poor bioavailability issues. |
| 资助项目 | World Class University (WCU) project of South Korea[R31-2008-000-10103-01] ; National Key Basic Research Program of China[2013CB932502] ; School of Pharmacy, Fudan University[00000000] ; Key Laboratory of Smart Drug Delivery, Fudan University, MOE PLA, China[SDD2011-02] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000209385400002 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277722]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Wang, Jingkang |
| 作者单位 | 1.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China; 2.Tianjin Univ, Sch Environm Sci & Engn, State Key Lab Engines, Tianjin 300072, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai 201203, Peoples R China; 4.PLA, Shanghai 201203, Peoples R China; 5.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China; 6.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 7.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China; 8.Univ Michigan, Dept Pharmaceut Sci, Coll Pharm, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | He, Huining,Ye, Junxiao,Sheng, Jianyong,et al. Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2013,7(1):9-19. |
| APA | He, Huining.,Ye, Junxiao.,Sheng, Jianyong.,Wang, Jianxin.,Huang, Yongzhuo.,...&Yang, Victor C..(2013).Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,7(1),9-19. |
| MLA | He, Huining,et al."Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 7.1(2013):9-19. |
入库方式： OAI收割
来源：上海药物研究所
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