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Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy

文献类型：期刊论文

作者Ye, Junxiao5; He, Huining5,6,7; Gong, Junbo5; Dong, Weibing5; Huang, Yongzhuo1,2,3,4; Wang, Jianxin1,2,3; Chen, Guanyi6; Yang, Victor C.7,8
刊名FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
出版日期2013-03
卷号7期号:1页码:20-28
关键词ultrasound-mediated targeted microbubbles cancer
ISSN号2095-0179
DOI10.1007/s11705-013-1311-z
文献子类Review
英文摘要With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in understanding the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultrasound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound-triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.
资助项目World Class University (WCU) project of South Korea[R31-2008-000-10103-01] ; National Key Basic Research Program of China[2013CB932502] ; School of Pharmacy, Fudan University[00000000] ; Key Laboratory of Smart Drug Delivery (Fudan University), MOE PLA, China[SDD2011-02]
WOS研究方向Engineering
语种英语
CSCD记录号CSCD:4862788
WOS记录号WOS:000209385400003
出版者HIGHER EDUCATION PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/277723]  
专题药物制剂研究中心
通讯作者He, Huining
作者单位1.PLA, Shanghai 201203, Peoples R China;
2.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China;
3.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai 201203, Peoples R China;
5.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China;
6.Tianjin Univ, Sch Environm Sci & Engn, State Key Lab Engines, Tianjin 300072, Peoples R China;
7.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China;
8.Univ Michigan, Dept Pharmaceut Sci, Coll Pharm, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714		 Ye, Junxiao,He, Huining,Gong, Junbo,et al. Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2013,7(1):20-28.
APA Ye, Junxiao.,He, Huining.,Gong, Junbo.,Dong, Weibing.,Huang, Yongzhuo.,...&Yang, Victor C..(2013).Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,7(1),20-28.
MLA Ye, Junxiao,et al."Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 7.1(2013):20-28.

入库方式： OAI收割

来源：上海药物研究所

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