A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor
文献类型：期刊论文
| 作者 | Zhang, Zhiwen1 ; Ma, Li2; Jiang, Shijun3; Liu, Zeying3; Huang, Jian1; Chen, Lingli1; Yu, Haijun1; Li, Yaping1
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| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2013-02-28 |
| 卷号 | 166期号:1页码:30-37 |
| 关键词 | Nanocarrier Self-assembly Teniposide Oral delivery Nanoparticles |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2012.12.018 |
| 文献子类 | Article |
| 英文摘要 | We attempted to improve the oral delivery of lipophilic teniposide to achieve higher drug concentration in tumor by self-assembled nanocarrier for further oral chemotherapy. The teniposide loaded self-assembled nanocarrier (TSN) was spherical nanometric particles with narrow size distribution. The intestinal absorption of teniposide from TSN was obviously improved 4.09- and 6.35-fold in duodenum and jejunum at 0.5 h after oral administration, then significantly decreased with the prolongation of time. The cellular uptake of TSN in Caco-2 cell monolayer was significantly enhanced over 3 folds and increased with incubation time. Moreover, TSN could be internalized into Caco-2 cell monolayer through clathrin-mediated endocytosis pathway, and then mainly transported into the systemic circulation via portal vein and intestinal lymphatic pathway. The pharmacokinetic results indicated that the AUC(0-t) value of TSN in rats was significantly improved 5.41-fold than that of teniposide solution, moreover, the teniposide concentration in tumor from TSN was obviously improved over 7-fold in tumor bearing mice. The captured image indicated that the oral administered TSN could specifically accumulate in tumor in the xenograft model. Therefore, the self-assembled nanocarrier was promising to enhance the oral delivery of lipophilic teniposide and its concentration in tumor for oral chemotherapy. (C) 2012 Elsevier B.V. All rights reserved. |
| WOS关键词 | INTESTINAL LYMPHATIC TRANSPORT ; SOLID LIPID NANOPARTICLES ; IN-VITRO CHARACTERISTICS ; FLOW BLOCKING APPROACH ; POLYMERIC MICELLES ; LIPOPHILIC DRUGS ; BIOAVAILABILITY ; RATS ; ABSORPTION ; PACLITAXEL |
| 资助项目 | National Basic Research Program of China[2009CB930304] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81270047] ; Shanghai Rising-Star Program[11QA1407900] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000315548200004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277724]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China; 3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Ma, Li,Jiang, Shijun,et al. A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor[J]. JOURNAL OF CONTROLLED RELEASE,2013,166(1):30-37. |
| APA | Zhang, Zhiwen.,Ma, Li.,Jiang, Shijun.,Liu, Zeying.,Huang, Jian.,...&Li, Yaping.(2013).A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor.JOURNAL OF CONTROLLED RELEASE,166(1),30-37. |
| MLA | Zhang, Zhiwen,et al."A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor".JOURNAL OF CONTROLLED RELEASE 166.1(2013):30-37. |
入库方式： OAI收割
来源：上海药物研究所
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