Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug
文献类型：期刊论文
| 作者 | Zhang, Zhiwen1 ; Huang, Jian2; Jiang, Shijun3; Liu, Zeying3; Gu, Wangwen1; Yu, Haijun1; Li, Yaping1
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2013-02-28 |
| 卷号 | 444期号:1-2页码:162-168 |
| 关键词 | Porous starch Self-assembly Nanoparticles Oral absorption Probucol |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2013.01.021 |
| 文献子类 | Article |
| 英文摘要 | The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption of lipophilic drugs. The lipophilic probucol loaded porous starch based self-assembled nano-delivery (PSN) system was developed and characterized. The probucol loaded nanocarrier (PLN) could be formed by self-assembly when PSN was dispersed into the gastrointestinal (GI) fluids. PLN was nanometer-sized particles with narrow size distribution and exhibited good stability in GI fluids. The aqueous solubility of probucol was increased over 50,000-fold by PSN delivery system and the cumulative release of lipophilic probucol was increased over 80% in GI fluids. The distribution of probucol in duodenum, jejunum and ileum was respectively improved 7.17, 15.99 and 33.61-fold by PSN. In particular, the oral bioavailability of probucol from PSN was greatly improved about 9.96-fold than that from free drug suspension and 3.71-fold higher than that from the directed adsorbed probucol loaded porous starch system, which effectively confirmed the high potential of the strategy in enhancing the oral absorption of lipophilic drugs. (C) 2013 Elsevier B. V. All rights reserved. |
| WOS关键词 | LIPID-BASED FORMULATIONS ; IN-VITRO CHARACTERISTICS ; WATER-SOLUBLE DRUGS ; BIOAVAILABILITY ; NANOPARTICLES ; RATS ; NANOCARRIERS ; PERSPECTIVE ; PARAMETERS ; MECHANISM |
| 资助项目 | National Basic Research Program of China[2009CB930304] ; National Basic Research Program of China[2013CB932503] ; National Basic Research Program of China[2013CB932704] ; Shanghai Rising-Star Program[11QA1407900] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000315298700021 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277727]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China; 3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Huang, Jian,Jiang, Shijun,et al. Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,444(1-2):162-168. |
| APA | Zhang, Zhiwen.,Huang, Jian.,Jiang, Shijun.,Liu, Zeying.,Gu, Wangwen.,...&Li, Yaping.(2013).Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug.INTERNATIONAL JOURNAL OF PHARMACEUTICS,444(1-2),162-168. |
| MLA | Zhang, Zhiwen,et al."Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug".INTERNATIONAL JOURNAL OF PHARMACEUTICS 444.1-2(2013):162-168. |
入库方式： OAI收割
来源：上海药物研究所
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