Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infrared absorption
文献类型：期刊论文
| 作者 | Guo, Chongshen2,3; Yin, Shu2; Yu, Haijun1 ; Liu, Shaoqin3; Dong, Qiang2; Goto, Takehiro2; Zhang, Zhiwen1; Li, Yaping1; Sato, Tsugio2
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:14页码:6469-6478 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c3nr01025b |
| 文献子类 | Article |
| 英文摘要 | Recently, photothermal ablation therapy (PTA) employing near-infrared radiation (NIR) has been extensively investigated as an emerging modality for cancer management. However, the clinical translation of this promising approach is limited by the lack of PTA agents with broad NIR absorption, low cost and high photothermal conversion efficiency. Herein, we have developed PEGylated homogeneous CsxWO3 nanorods (a mean size similar to 69.3 nm x 12.8 nm) with broad photo-absorption (780-2500 nm) as a novel NIR absorbent for PTA treatment of human cancer. The prepared CsxWO3 nanocrystals displayed strong near-infrared optical absorption with a high molar extinction coefficient (e.g. 4.8 x 10(10) M-1 cm(-1) at 980 nm), thus generated significant amounts of heat upon excitation with near-infrared light. The PTA study in two human carcinoma cell lines (i.e. A549 lung cancer cells and HeLa ovarian cancer cells) demonstrated that CsxWO3 nanorods can efficiently cause cell death via hyperthermia induced lysosome destruction, cytoskeleton protein degradation, DNA damage and thereafter cellular necrosis or apoptosis. Our study also confirmed the migration of healthy cells migrated from unirradiated areas to dead cell cycle, which is essential for tissue reconstruction and wound healing after photodestruction of tumor tissue. The prompted results reported in the current study imply the promising potential of CsxWO3 nanorods for application in PTA cancer therapy. |
| WOS关键词 | GOLD NANOPARTICLES ; IN-VITRO ; CELLS ; GRAPHENE ; CHEMOTHERAPY ; DESTRUCTION ; EFFICIENCY ; NANOCAGES ; DELIVERY ; PLATFORM |
| 资助项目 | Ministry of Education, Culture, Sports and Science for Technology of Japan (MEXT)[00000000] ; Adaptable and Seamless Technology transfer Program through target-driven RD, JST[00000000] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2012CB932502] ; Nippon Sheet Glass Foundation for Materials Science and Engineering[00000000] ; [23241025] ; [25289245] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000321014900039 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277790]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yin, Shu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan; 3.Harbin Inst Technol, Minist Educ, Key Lab Microsyst & Micronanostruct Mfg, Harbin 150080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Chongshen,Yin, Shu,Yu, Haijun,et al. Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infrared absorption[J]. NANOSCALE,2013,5(14):6469-6478. |
| APA | Guo, Chongshen.,Yin, Shu.,Yu, Haijun.,Liu, Shaoqin.,Dong, Qiang.,...&Sato, Tsugio.(2013).Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infrared absorption.NANOSCALE,5(14),6469-6478. |
| MLA | Guo, Chongshen,et al."Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infrared absorption".NANOSCALE 5.14(2013):6469-6478. |
入库方式： OAI收割
来源：上海药物研究所
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