Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery
文献类型：期刊论文
| 作者 | Sun, Yajuan5; Dong, Weibing3,6; Wang, Huiyuan1 ; Huang, Yongzhuo1; Gu, Huike5; Yang, Victor C.2,4; Gong, Junbo5,6
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| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:8页码:2489-2495 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c3py21157f |
| 文献子类 | Article |
| 英文摘要 | Nanorods are capable of enhanced intracellular delivery and prolonged blood circulation over their spherical counterparts, and thus can be used as unmatched drug carriers for cancer chemotherapy. An innovative method was developed to synthesize size-tunable, PMAA@chitosan-based, hollow polymeric nanorods for intracellular delivery, by using mesoporous silica nanorod templates. The morphology of the polymeric hollow nanorods was examined by TEM and FT-IR spectra, which indicated a homogeneous three-dimensional structure. An uptake study using human lung carcinoma A-549 cell lines revealed highly efficient cell internalization of the FITC-labeled nanorods, suggesting the potential of utilizing these nanorods as carriers in achieving effective intracellular drug delivery. Cell viability studies of the docetaxel-loaded nanorods yielded consistent results, as the drug-loaded nanorods produced a significantly higher inhibition of the growth of A-549 tumor cells when compared with treatment by free docetaxel. Overall, this preliminary in vitro investigation sheds light on the use of prepared hollow polymeric nanorods for drug delivery applications. |
| WOS关键词 | MESOPOROUS SILICA NANORODS ; DRUG-DELIVERY ; GOLD NANORODS ; POLYMERIC MICROSPHERES ; TEST TUBES ; NANOPARTICLES ; SYSTEMS ; ENCAPSULATION ; THERAPEUTICS ; FABRICATION |
| 资助项目 | National Basic Research Program of China (973 Program)[2013CB932503] ; National Science Foundation of China[NNSFC 21176173] ; Tianjin Municipal Natural Science Foundation[10JCYBJC14200] ; State Key Laboratory of Chemical Engineering of China[SKL-CHE-11B02] ; Innovation Foundation of Tianjin University[60302068] ; MEST[R31-2008-000-10103-01] ; NRE of South Korea[00000000] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000316289600018 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277803]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA 3.Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China; 4.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China; 5.Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China; 6.Tianjin Univ, Sch Pharm, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Yajuan,Dong, Weibing,Wang, Huiyuan,et al. Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery[J]. POLYMER CHEMISTRY,2013,4(8):2489-2495. |
| APA | Sun, Yajuan.,Dong, Weibing.,Wang, Huiyuan.,Huang, Yongzhuo.,Gu, Huike.,...&Gong, Junbo.(2013).Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery.POLYMER CHEMISTRY,4(8),2489-2495. |
| MLA | Sun, Yajuan,et al."Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery".POLYMER CHEMISTRY 4.8(2013):2489-2495. |
入库方式： OAI收割
来源：上海药物研究所
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