Nano-based Drug Delivery System Enhances the Oral Absorption of Lipophilic Drugs with Extensive Presystemic Metabolism
文献类型：期刊论文
| 作者 | Zhang, Zhiwen ; Gao, Fang; Jiang, Shijun; Ma, Li; Li, Yaping
|
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2012-10 |
| 卷号 | 13期号:8页码:1110-1118 |
| 关键词 | Nanosystems lipophilic drugs presystemic metabolism oral delivery bioavailability |
| ISSN号 | 1389-2002 |
| DOI | 10.2174/138920012802850100 |
| 文献子类 | Review |
| 英文摘要 | Oral administration remains the most preferred route for the treatment of many diseases due to its convenience and adaptability. However, the presystemic metabolism may be an important barrier that prevents lipophilic drugs from achieving their pharmacological effects following oral delivery. Nano-based drug delivery system provides an effective strategy to reduce the presystemic metabolism and increase the systemic exposure of lipophilic drugs. In this review, we described the physiological factors affecting the presystemic metabolism of lipophilic drugs, intestinal transport of nanosystems, strategy of nanosystems to avoid the presystemic metabolism, and the current application of various oral nanosystems including lipid and polymeric nanocarriers. The nano-based drug delivery system has a lot of potential for reducing the presystemic metabolism and enhancing the bioavailability of orally administrated lipophilic drugs. |
| WOS关键词 | SOLID LIPID NANOPARTICLES ; POLYUNSATURATED FATTY-ACIDS ; WATER-SOLUBLE DRUGS ; IN-VIVO EVALUATION ; CYCLOSPORINE-A ; PLGA NANOPARTICLES ; BIODEGRADABLE NANOPARTICLES ; BIOAVAILABILITY ASSESSMENT ; POLYMERIC NANOPARTICLES ; FORMULATION DEVELOPMENT |
| 资助项目 | National Basic Research Program of China[2009-CB930304] ; National Basic Research Program of China[2007CB935800] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[30901866] ; Shanghai Nanomedicine Program[1052nm06300] ; Shanghai Rising- Star Program[11QA1407900] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000308791700008 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277924]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, Yaping |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiwen,Gao, Fang,Jiang, Shijun,et al. Nano-based Drug Delivery System Enhances the Oral Absorption of Lipophilic Drugs with Extensive Presystemic Metabolism[J]. CURRENT DRUG METABOLISM,2012,13(8):1110-1118. |
| APA | Zhang, Zhiwen,Gao, Fang,Jiang, Shijun,Ma, Li,&Li, Yaping.(2012).Nano-based Drug Delivery System Enhances the Oral Absorption of Lipophilic Drugs with Extensive Presystemic Metabolism.CURRENT DRUG METABOLISM,13(8),1110-1118. |
| MLA | Zhang, Zhiwen,et al."Nano-based Drug Delivery System Enhances the Oral Absorption of Lipophilic Drugs with Extensive Presystemic Metabolism".CURRENT DRUG METABOLISM 13.8(2012):1110-1118. |
入库方式： OAI收割
来源：上海药物研究所
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