Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells
文献类型：期刊论文
| 作者 | Zhang, Xinxin ; Guo, Shiyan; Fan, Rong; Yu, Miaorong; Li, Feifei; Zhu, Chunliu; Gan, Yong
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012-10 |
| 卷号 | 33期号:29页码:7103-7114 |
| 关键词 | Dual-functional liposome Galactosyl conjugated pluronic P123 Tumor targeting Multidrug resistance Mitoxantrone Hepatocellular carcinoma |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2012.06.048 |
| 文献子类 | Article |
| 英文摘要 | The purpose of this study was to design and evaluate the dual-functional liposome (LPG) with synthetic polymeric nano-biomaterial (Gal-P123) that targets cancer cells and reverses multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The mitoxantrone (MX) loaded LPG (MX-LPG) was about 100 nm in diameter, spherically shaped, and had an encapsulation efficiency of 97.3%. The cytotoxicity and cellular uptake of MX-LPG were evaluated in HCC Huh-7 cells. BCRP-overexpressing MDCKII/BCRP cells were used to certify the inhibitory effect of LPG on drug efflux transporter. Compared with MX, MX-LPG had 2.3-fold higher cytotoxicity in Huh-7 cells and a 14.9-fold increase in cellular MX accumulation in MDCKII/BCRP cells. The pharmacokinetic study in rats showed that LPG significantly prolonged the circulation time and enhanced the bioavailability of MX. Moreover, MX-LPG increased antitumor activity and improved selectivity in BALB/c mice bearing orthotopic xenograft HCC tumors. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DRUG-RESISTANCE ; ANTICANCER-DRUG ; POLYMERIC MICELLES ; BLOCK-COPOLYMERS ; CANCER-CELLS ; DELIVERY ; PACLITAXEL ; THERAPY ; LIVER ; PHARMACOKINETICS |
| 资助项目 | National Natural Science Foundation of China[30901865] ; Natural Science Foundation of Hebei Province of China[C2011319010] ; National Key Technology Research and Development Program of China[2012ZX09301001-001] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000308269600021 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277933]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xinxin,Guo, Shiyan,Fan, Rong,et al. Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells[J]. BIOMATERIALS,2012,33(29):7103-7114. |
| APA | Zhang, Xinxin.,Guo, Shiyan.,Fan, Rong.,Yu, Miaorong.,Li, Feifei.,...&Gan, Yong.(2012).Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells.BIOMATERIALS,33(29),7103-7114. |
| MLA | Zhang, Xinxin,et al."Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells".BIOMATERIALS 33.29(2012):7103-7114. |
入库方式： OAI收割
来源：上海药物研究所
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