Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells
文献类型：期刊论文
| 作者 | Chen, Yu3; Yin, Qi2 ; Ji, Xiufeng2; Zhang, Shengjian1,4; Chen, Hangrong3; Zheng, Yuanyi5; Sun, Yang5; Qu, Haiyun3; Wang, Zheng3; Li, Yaping2
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2012-10 |
| 卷号 | 33期号:29页码:7126-7137 |
| 关键词 | Mesoporous Hollow MRI Ultrasonography Cancer therapy Diagnosis |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2012.06.059 |
| 文献子类 | Article |
| 英文摘要 | Nano-biotechnology has been introduced into cancer theranostics by engineering a new generation of highly versatile hybrid mesoporous composite nanocapsules (HMCNs) for manganese-based pH-responsive dynamic T-1-weighted magnetic resonance imaging (MRI) to efficiently respond and detect the tumor acidic microenvironment, which was further integrated with ultrasonographic function based on the intrinsic unique hollow nanostructures of HMCNs for potentially in vitro and in vivo dual-modality cancer imaging. The manganese oxide-based multifunctionalization of hollow mesoporous silica nanoparticles was achieved by an in situ redox reaction using mesopores as the nanoreactors. Due to the dissolution nature of manganese oxide nanoparticles under weak acidic conditions, the relaxation rate r(1) of manganese-based mesoporous MRI-T-1 contrast agents (CAs) could reach 8.81 mM(-1)s(-1), which is a 11-fold magnitude increase compared to the neutral condition, and is almost two times higher than commercial Gd-III-based complex agents. This is also the highest r(1) value ever reported for manganese oxide nanoparticles-based MRI-T-1 CAs. In addition, the hollow interiors and thin mesoporous silica shells endow HMCNs with the functions of CAs for efficient in vitro and in vivo ultrasonography under both harmonic- and B-modes. Importantly, the well-defined mesopores and large hollow interiors of HMCNs could encapsulate and deliver anticancer agents (doxorubicin) intracellularly to circumvent the multidrug resistance (MDR) of cancer cells and restore the anti-proliferative effect of drugs by nanoparticle-mediated endocytosis process, intracellular drug release and P-gp inhibition/ATP depletion in cancer cells. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DRUG-DELIVERY ; MAGNETIC-RESONANCE ; CONTROLLED-RELEASE ; MULTIDRUG-RESISTANCE ; CONTRAST AGENTS ; NANOCAPSULES ; SHELL ; NANOTHERANOSTICS ; NANOCOMPOSITES ; DOXORUBICIN |
| 资助项目 | National Basic Research Program of China (973 Program)[2011CB707905] ; National Basic Research Program of China (973 Program)[2010CB934000] ; National Basic Research Program of China (973 Program)[2012CB932500] ; Shanghai Rising-Star Program[10QH1402800] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[50823007] ; National Nature Science Foundation of China[50972154] ; National Nature Science Foundation of China[51072212] ; National Nature Science Foundation of China[51102259] ; National Nature Science Foundation of China[30925041] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000308269600023 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277934]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Hangrong |
| 作者单位 | 1.Fudan Univ, Shanghai Med Coll, Canc Hosp Inst, Dept Radiol, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China; 4.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 5.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Yu,Yin, Qi,Ji, Xiufeng,et al. Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells[J]. BIOMATERIALS,2012,33(29):7126-7137. |
| APA | Chen, Yu.,Yin, Qi.,Ji, Xiufeng.,Zhang, Shengjian.,Chen, Hangrong.,...&Shi, Jianlin.(2012).Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells.BIOMATERIALS,33(29),7126-7137. |
| MLA | Chen, Yu,et al."Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells".BIOMATERIALS 33.29(2012):7126-7137. |
入库方式： OAI收割
来源：上海药物研究所
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