Magnetic Nanoparticles for MRI of Brain Tumors
文献类型：期刊论文
| 作者 | Wang, Jianxin1,4; Huang, Yongzhuo2,4 ; David, Allan E.4; Chertok, Beata4; Zhang, Lei4; Yu, Faquan4; Yang, Victor C.3,4
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| 刊名 | CURRENT PHARMACEUTICAL BIOTECHNOLOGY
 |
| 出版日期 | 2012-09 |
| 卷号 | 13期号:12页码:2403-2416 |
| 关键词 | Brain tumors imaging MRI iron oxide nanoparticles targeting |
| ISSN号 | 1389-2010 |
| DOI | 10.2174/138920112803341824 |
| 文献子类 | Review |
| 英文摘要 | Despite advances in surgery and drug discovery, brain tumors remain fatal diseases. Early detection and diagnosis of brain tumors is of great importance for improving treatment outcomes. Magnetic resonance imaging (MRI) is a prominent, clinically-relevant imaging modality because of its excellent tissue contrast resolution, direct multiplanar imaging and increased sensitivity to edema. MRI utility is further enhanced with the use of magnetic iron oxide nanoparticles, which can function as both a contrast agent for imaging and as a drug delivery vehicle for treating brain cancer. In this review, the principles of various imaging modalities for brain tumors are discussed with focus on monocrystalline iron oxide nanoparticle (MION)-based MRI contrast agents. A summary is given on the mechanism of contrast effect, magnetophoretic mobility and magnetic retention, and strategies to enhance tumor selectivity, increase spatial resolution and reduce nonspecific uptake of MION. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; CENTRAL-NERVOUS-SYSTEM ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; IN-VIVO MRI ; QUANTUM DOTS ; ISCHEMIC-STROKE ; CONTRAST AGENTS ; DRUG-DELIVERY ; GENE DELIVERY ; PHYSICOCHEMICAL CHARACTERISTICS |
| 资助项目 | NIH[CA114612] ; NIH[NS066945] ; World Class University (WCU) project of the MEST[R31-2008-000-10103-01] ; NRF of South Korea[00000000] ; National Science Foundation of China[30873446] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000309661600010 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277950]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Yang, Victor C. |
| 作者单位 | 1.Fudan Univ, Dept Pharmaceut, Coll Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Met Med, Shangha 201203, Peoples R China; 3.Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China 4.Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA; |
| 推荐引用方式 GB/T 7714 | Wang, Jianxin,Huang, Yongzhuo,David, Allan E.,et al. Magnetic Nanoparticles for MRI of Brain Tumors[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2012,13(12):2403-2416. |
| APA | Wang, Jianxin.,Huang, Yongzhuo.,David, Allan E..,Chertok, Beata.,Zhang, Lei.,...&Yang, Victor C..(2012).Magnetic Nanoparticles for MRI of Brain Tumors.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,13(12),2403-2416. |
| MLA | Wang, Jianxin,et al."Magnetic Nanoparticles for MRI of Brain Tumors".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 13.12(2012):2403-2416. |
入库方式： OAI收割
来源：上海药物研究所
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