TAT-modified nanosilver for combating multidrug-resistant cancer
文献类型：期刊论文
| 作者 | Liu, Jinhua1,2; Zhao, Yongxing1; Guo, Qianqian1,2; Wang, Zhao2; Wang, Huiyuan2 ; Yang, Yongxin2; Huang, Yongzhuo2,3
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012-09 |
| 卷号 | 33期号:26页码:6155-6161 |
| 关键词 | Silver nanoparticle Cell-penetrating peptide Multidrug resistance Cancer TAT |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2012.05.035 |
| 文献子类 | Article |
| 英文摘要 | A nanopharmaceutical system using TAT-enhanced cell/tissue penetration strategy was developed for multidrug-resistant (MDR) cancer treatment, in which nanocrystalline silver with mean size of 8 nm modified with TAT cell-penetrating peptide (termed AgNP-TAT) displayed extraordinary antitumor activity in both MDR cells and non-resistant cells at an indiscriminating manner. Such anti-MDR effect is presumably due to the size-exclusion effect, by which the nanoparticles are too large to be pumped out. Of note, AgNP-TAT showed significant enhancement in killing tumor cells, e.g. up to 24 fold higher compared to its counterpart without TAT-modification. The animal studies further confirmed the success of our strategy that AgNP-TAT was able to effectively inhibit the tumor growth in the mice bearing malignant melanoma at a dose of 1 nmol/kg, compared with the effective dose (4.3 mu mol/kg) of doxorubicin. AgNP-TAT also showed significantly reduced adverse toxicity in vivo. It indicates AgNP-TAT could be a class of nano drug for MDR cancer treatment. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | P-GLYCOPROTEIN ; PROTEIN TRANSDUCTION ; DRUG-BINDING ; DELIVERY ; CELLS ; NANOPARTICLES ; TRACKING ; INSIGHTS ; EFFLUX |
| 资助项目 | NSFC, China[91029743] ; NSFC, China[81172996] ; Shanghai Pu-jiang Scholar Program[00000000] ; School of Pharmacy, Fudan University[00000000] ; Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), MOE PLA, China[00000000] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000306720400019 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277980]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Fudan Univ, Minist Educ, Key Lab Smart Drug Delivery, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jinhua,Zhao, Yongxing,Guo, Qianqian,et al. TAT-modified nanosilver for combating multidrug-resistant cancer[J]. BIOMATERIALS,2012,33(26):6155-6161. |
| APA | Liu, Jinhua.,Zhao, Yongxing.,Guo, Qianqian.,Wang, Zhao.,Wang, Huiyuan.,...&Huang, Yongzhuo.(2012).TAT-modified nanosilver for combating multidrug-resistant cancer.BIOMATERIALS,33(26),6155-6161. |
| MLA | Liu, Jinhua,et al."TAT-modified nanosilver for combating multidrug-resistant cancer".BIOMATERIALS 33.26(2012):6155-6161. |
入库方式： OAI收割
来源：上海药物研究所
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