Multifunctional drug delivery system for targeting tumor and its acidic microenvironment
文献类型：期刊论文
| 作者 | Shen, Ming3,4,5; Huang, Yongzhuo4,5,6 ; Han, Limei4,5; Qin, Jing4,5; Fang, Xiaoling4,5; Wang, Jianxin4,5; Yang, Victor C.1,2
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| 刊名 | JOURNAL OF CONTROLLED RELEASE
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| 出版日期 | 2012-08-10 |
| 卷号 | 161期号:3页码:884-892 |
| 关键词 | Polymeric nanoparticles Multifunctional targeting pH-sensitive Folate acid PEGylation |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2012.05.013 |
| 文献子类 | Article |
| 英文摘要 | Effective targeting drug delivery for cancer therapy still remains a formidable challenge due to the complication and heterogeneity of malignant tumors. Herein, a multifunctional targeting strategy was proposed, in which a novel pH-sensitive polymethacrylates (PMA)-grafted poly(amidoamine) (PAMAM) nano delivery system was designed to be responsive to the acidic tumor microenvironment, and thereby trigger drug release in the intra-tumoral space. In addition, folate-PEGylation was applied to modify the surface of PMA-PAMAM nanoparticles in order to enhance tumor selectivity via both active and passive targeting mechanisms: folate receptor targeting, long circulation and EPR effect. The utility and efficacy of such system was demonstrated both in vitro and in vivo. Tumor drug accumulation was significantly enhanced by folate-PEGylated PMA-PAMAM nanoparticles, and such observation corresponded to their strong inhibition of tumor growth in tumor-bearing mice, demonstrating the success of the multifunctional targeting delivery. This multifunctional targeting strategy provides a promising solution to improve targeting drug delivery for combating the complex cancer diseases. (c) 2012 Elsevier B.V. All rights reserved. |
| WOS关键词 | POLY(ETHYLENE GLYCOL) ; PACLITAXEL DELIVERY ; GENE DELIVERY ; CELL LINES ; NANOPARTICLES ; FOLATE ; DENDRIMERS ; COPOLYMER ; CANCER ; PEG |
| 资助项目 | National Science Foundation of China[30873446] ; School of Pharmacy, Fudan University[00000000] ; Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education/PLA, China[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000308077000021 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277987]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Wang, Jianxin |
| 作者单位 | 1.Tianjin Med Univ, Sch Pharm, Tianjin 30070, Peoples R China 2.Univ Michigan, Dept Pharmaceut Sci, Coll Pharm, Ann Arbor, MI 48109 USA; 3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Canc Inst, Shanghai 200032, Peoples R China; 4.PLA, Shanghai 201203, Peoples R China; 5.Fudan Univ, Dept Pharmaceut, Sch Pharm, Key Lab Smart Drug Delivery,Minist Educ, Shanghai 201203, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shen, Ming,Huang, Yongzhuo,Han, Limei,et al. Multifunctional drug delivery system for targeting tumor and its acidic microenvironment[J]. JOURNAL OF CONTROLLED RELEASE,2012,161(3):884-892. |
| APA | Shen, Ming.,Huang, Yongzhuo.,Han, Limei.,Qin, Jing.,Fang, Xiaoling.,...&Yang, Victor C..(2012).Multifunctional drug delivery system for targeting tumor and its acidic microenvironment.JOURNAL OF CONTROLLED RELEASE,161(3),884-892. |
| MLA | Shen, Ming,et al."Multifunctional drug delivery system for targeting tumor and its acidic microenvironment".JOURNAL OF CONTROLLED RELEASE 161.3(2012):884-892. |
入库方式： OAI收割
来源：上海药物研究所
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