Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents
文献类型：期刊论文
| 作者 | Chen, Yu4; Gao, Yu3; Chen, Hangrong4; Zeng, Deping1,2; Li, Yaping3 ; Zheng, Yuanyi5; Li, Faqi1,2; Ji, Xiufeng3; Wang, Xia4; Chen, Feng4
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2012-04-24 |
| 卷号 | 22期号:8页码:1586-1597 |
| 关键词 | mesoporous silica selective etching emulsions liposomes hydrophobic agents |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201102052 |
| 文献子类 | Article |
| 英文摘要 | A novel drug-formulation protocol is developed to solve the delivery problem of hydrophobic drug molecules by using inorganic mesoporous silica nanocapsules (IMNCs) as an alternative to traditional organic emulsions and liposomes while preserving the advantages of inorganic materials. The unique structures of IMNCs are engineered by a novel fluoride-silica chemistry based on a structural difference-based selective etching strategy. The prepared IMNCs combine the functions of organic nanoemulsions or nanoliposomes with the properties of inorganic materials. Various spherical nanostructures can be fabricated simply by varying the synthetic parameters. The drug loading amount of a typical highly hydrophobic anticancer drug-camptothecin (CPT) in IMNCs reaches as high as 35.1 wt%. The intracellular release of CPT from carriers is demonstrated in situ. In addition, IMNCs can play the role of organic nanoliposome (multivesicular liposome) in co-encapsulating and co-delivering hydrophobic (CPT) and hydrophilic (doxorubicin, DOX) anticancer drugs simultaneously. The co-delivery of multi-drugs in the same carrier and the intracellular release of the drug combinations enables a drug delivery system with efficient enhanced chemotherapeutic effect for DOX-resistant MCF-7/ADR cancer cells. The special IMNCs-based inorganic nanoemulsion, as a proof-of-concept, can also be employed successfully to encapsulate and deliver biocompatible hydrophobic perfluorohexane (PFH) molecules for high intensity focused ultrasound (HIFU) synergistic therapy ex vivo and in vivo. Based on this novel design strategy, a wide range of inorganic material systems with similar inorganic nanoemulsion or nanoliposome functions will be developed to satisfy varied clinical requirements. |
| WOS关键词 | INTENSITY FOCUSED ULTRASOUND ; DRUG-DELIVERY ; ANTICANCER DRUGS ; TARGETED DELIVERY ; NANOPARTICLES ; CANCER ; SYSTEMS ; CELL ; DOXORUBICIN ; NANORATTLE |
| 资助项目 | National Basic Research Program of China (973 Program)[2011CB707905] ; National Basic Research Program of China (973 Program)[2009CB930304] ; National Basic Research Program of China (973 Program)[2010CB934000] ; Shanghai Rising-Star Program[10QH1402800] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[50823007] ; National Nature Science Foundation of China[51072212] ; National Nature Science Foundation of China[51102259] ; Science and Technology Commission of Shanghai[11nm0506500] ; Science and Technology Commission of Shanghai[10430712800] ; Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201001] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000302794400004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278112]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Yu |
| 作者单位 | 1.Chongqing Med Univ, Coll Biomed Engn, Minist Sci & Technol, Chongqing Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; 2.Chongqing Med Univ, State Key Lab Ultrasound Engn Med, Chongqing 400016, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China; 5.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yu,Gao, Yu,Chen, Hangrong,et al. Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(8):1586-1597. |
| APA | Chen, Yu.,Gao, Yu.,Chen, Hangrong.,Zeng, Deping.,Li, Yaping.,...&Shi, Jianlin.(2012).Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents.ADVANCED FUNCTIONAL MATERIALS,22(8),1586-1597. |
| MLA | Chen, Yu,et al."Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents".ADVANCED FUNCTIONAL MATERIALS 22.8(2012):1586-1597. |
入库方式： OAI收割
来源：上海药物研究所
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