An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs
文献类型：期刊论文
| 作者 | Wang, Shuo3; Wang, Hua3; Liang, Wenquan3; Huang, Yongzhuo1,2,4
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| 刊名 | NANOSCALE RESEARCH LETTERS
 |
| 出版日期 | 2012-04-13 |
| 卷号 | 7 |
| 关键词 | Poor solubility Drug delivery Nano emulsion Nanoparticle Dihydroartemisinin |
| ISSN号 | 1931-7573 |
| DOI | 10.1186/1556-276X-7-219 |
| 文献子类 | Article |
| 英文摘要 | Poor drugability problems are commonly seen in a class of chemical entities with poor solubility in water and oil, and moreover, physicochemical instability of these compounds poses extra challenges in design of dosage forms. Such problems contribute a significant high failure rate in new drug development. A hybrid nanoparicle-in-oil-in-water (N/O/W) submicron emulsion was proposed for improved delivery of poorly soluble and unstable drugs (e.g., dihydroartemisinin (DHA)). DHA is known for its potent antimalarial effect and antitumor activity. However, its insolubility and instability impose big challenges for formulations, and so far, no injectable dosage forms are clinically available yet. Therefore, an injectable DHA N/O/W system was developed. Unlike other widely-explored systems (e.g., liposomes, micelles, and emulsions), in which low drug load and only short-term storage are often found, the hybrid submicron emulsion possesses three-fold higher drug-loading capacity than the conventional O/W emulsion. Of note, it can be manufactured into a freeze-drying form and can render its storage up to 6 months even in room temperature. The in vivo studies demonstrated that the PK profiles were significantly improved, and this injectable system was effective in suppressing tumor growth. The strategy provides a useful solution to effective delivery of such a class of drugs. |
| WOS关键词 | CELLS ; DIHYDROARTEMISININ ; ARTEMISININ ; FORMULATION ; VIVO |
| 资助项目 | National Natural Science Foundation of China (NSFC)[30873176] ; National Natural Science Foundation of China (NSFC)[81172996] ; Shanghai Pujiang Scholarship[00000000] ; School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), MOE PLA, China[00000000] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000309075400001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278118]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Liang, Wenquan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.PLA, Shanghai 201203, Peoples R China 3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 4.Fudan Univ, Key Lab Smart Drug Delivery, MOE, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Shuo,Wang, Hua,Liang, Wenquan,et al. An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs[J]. NANOSCALE RESEARCH LETTERS,2012,7. |
| APA | Wang, Shuo,Wang, Hua,Liang, Wenquan,&Huang, Yongzhuo.(2012).An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs.NANOSCALE RESEARCH LETTERS,7. |
| MLA | Wang, Shuo,et al."An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs".NANOSCALE RESEARCH LETTERS 7(2012). |
入库方式： OAI收割
来源：上海药物研究所
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